The Effects of a Red-Light Controllable Nitric Oxide Donor, NORD-1, on Erectile Dysfunction in Rats with Streptozotocin Induced Diabetes Mellitus
Purpose: Patients with diabetes mellitus (DM) often exhibit refractory erectile dysfunction (ED). Red-light-controllable nitric oxide donor (NORD-1) and red-light irradiation have successfully enhanced erectile function in intact rats. In this study, we investigated whether the combination of NORD...
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Korean Society for Sexual Medicine and Andrology
2025-01-01
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| Series: | The World Journal of Men's Health |
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| author | Yuji Hotta Kyoya Oyama Takuma Yoshida Naoya Ieda Taiki Mori Yasuhiro Horita Tomoya Kataoka Yoko Furukawa-Hibi Susumu Ohya Hidehiko Nakagawa Kazunori Kimura |
| author_facet | Yuji Hotta Kyoya Oyama Takuma Yoshida Naoya Ieda Taiki Mori Yasuhiro Horita Tomoya Kataoka Yoko Furukawa-Hibi Susumu Ohya Hidehiko Nakagawa Kazunori Kimura |
| author_sort | Yuji Hotta |
| collection | DOAJ |
| description | Purpose: Patients with diabetes mellitus (DM) often exhibit refractory erectile dysfunction (ED). Red-light-controllable nitric
oxide donor (NORD-1) and red-light irradiation have successfully enhanced erectile function in intact rats. In this study, we
investigated whether the combination of NORD-1 and red-light irradiation effectively treated ED in streptozotocin (STZ)-
treated rats with DM.
Materials and Methods: Seven-week-old male Sprague-Dawley rats were used in this study. Rats in the DM and sham groups
received intravenous STZ (50 mg/kg) and saline, respectively. One week after treatment, the blood glucose level of rats in the
DM group was >250 mg/dL. Five weeks after the treatment, we performed a functional study by measuring intracavernous
pressure (ICP) under cavernous nerve stimulation before and after NORD-1 treatment with and without light irradiation. Additionally,
we performed an isometric tension study using the corpus cavernosum of rats treated with NORD-1 or the control
compound, SiR650.
Results: The ICP/mean arterial pressure (MAP) ratio was significantly lower in the DM group than in the sham group before
and after NORD-1 treatment without light irradiation (both p<0.05). After NORD-1 treatment with light irradiation, the ICP/
MAP ratio in the sham and DM groups was significantly enhanced than before and after NORD-1 treatment without light
irradiation (all p<0.05). The ICP/MAP ratio in the DM group after NORD-1 with light irradiation was similar to that in the
sham group under normal conditions before NORD-1 treatment. Moreover, the systemic blood pressure was not affected by
NORD-1 or light irradiation. In the tension study, the corpus cavernosum of rats treated with SiR650 was not changed by red
light in the sham or DM groups. However, the rats treated with NORD-1 were strongly relaxed by red light in both groups.
Conclusions: NORD-1 and red-light irradiation could improve ED in the presence of DM without lowering blood pressure. |
| format | Article |
| id | doaj-art-9a41024bb6214df4ac0c8183d89e5dba |
| institution | Kabale University |
| issn | 2287-4208 2287-4690 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj-art-9a41024bb6214df4ac0c8183d89e5dba2025-01-03T05:11:31ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902025-01-0143119720410.5534/wjmh.230362The Effects of a Red-Light Controllable Nitric Oxide Donor, NORD-1, on Erectile Dysfunction in Rats with Streptozotocin Induced Diabetes MellitusYuji Hotta0https://orcid.org/0000-0002-9474-7775Kyoya Oyama1https://orcid.org/0009-0003-7207-6805Takuma Yoshida2https://orcid.org/0009-0007-5127-0886Naoya Ieda3https://orcid.org/0000-0001-7810-9418Taiki Mori4https://orcid.org/0000-0002-8738-6190Yasuhiro Horita5https://orcid.org/0000-0003-1191-8792Tomoya Kataoka6https://orcid.org/0000-0001-9683-4680Yoko Furukawa-Hibi7https://orcid.org/0000-0002-2126-5652Susumu Ohya8https://orcid.org/0000-0002-5765-0667Hidehiko Nakagawa9https://orcid.org/0000-0001-8435-4401Kazunori Kimura10https://orcid.org/0000-0002-2473-4776Department of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, NagoyaDepartment of Hospital Pharmacy, Nagoya City University Graduate School of Pharmaceutical Sciences, NagoyaDepartment of Hospital Pharmacy, Nagoya City University Graduate School of Pharmaceutical Sciences, NagoyaDepartment of Organic and Medicinal Chemistry, Nagoya City University Graduate School of Pharmaceutical Sciences, NagoyaDepartment of Hospital Pharmacy, Nagoya City University Graduate School of Pharmaceutical Sciences, NagoyaDepartment of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, NagoyaDepartment of Pharmacology, Chiba Institute of Science, ChoshiDepartment of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, NagoyaDepartment of Pharmacology, Nagoya City University Graduate School of Medical Sciences, NagoyaDepartment of Organic and Medicinal Chemistry, Nagoya City University Graduate School of Pharmaceutical Sciences, NagoyaDepartment of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, NagoyaPurpose: Patients with diabetes mellitus (DM) often exhibit refractory erectile dysfunction (ED). Red-light-controllable nitric oxide donor (NORD-1) and red-light irradiation have successfully enhanced erectile function in intact rats. In this study, we investigated whether the combination of NORD-1 and red-light irradiation effectively treated ED in streptozotocin (STZ)- treated rats with DM. Materials and Methods: Seven-week-old male Sprague-Dawley rats were used in this study. Rats in the DM and sham groups received intravenous STZ (50 mg/kg) and saline, respectively. One week after treatment, the blood glucose level of rats in the DM group was >250 mg/dL. Five weeks after the treatment, we performed a functional study by measuring intracavernous pressure (ICP) under cavernous nerve stimulation before and after NORD-1 treatment with and without light irradiation. Additionally, we performed an isometric tension study using the corpus cavernosum of rats treated with NORD-1 or the control compound, SiR650. Results: The ICP/mean arterial pressure (MAP) ratio was significantly lower in the DM group than in the sham group before and after NORD-1 treatment without light irradiation (both p<0.05). After NORD-1 treatment with light irradiation, the ICP/ MAP ratio in the sham and DM groups was significantly enhanced than before and after NORD-1 treatment without light irradiation (all p<0.05). The ICP/MAP ratio in the DM group after NORD-1 with light irradiation was similar to that in the sham group under normal conditions before NORD-1 treatment. Moreover, the systemic blood pressure was not affected by NORD-1 or light irradiation. In the tension study, the corpus cavernosum of rats treated with SiR650 was not changed by red light in the sham or DM groups. However, the rats treated with NORD-1 were strongly relaxed by red light in both groups. Conclusions: NORD-1 and red-light irradiation could improve ED in the presence of DM without lowering blood pressure.diabetes mellituserectile dysfunctionnitric oxidered lightrelaxation |
| spellingShingle | Yuji Hotta Kyoya Oyama Takuma Yoshida Naoya Ieda Taiki Mori Yasuhiro Horita Tomoya Kataoka Yoko Furukawa-Hibi Susumu Ohya Hidehiko Nakagawa Kazunori Kimura The Effects of a Red-Light Controllable Nitric Oxide Donor, NORD-1, on Erectile Dysfunction in Rats with Streptozotocin Induced Diabetes Mellitus The World Journal of Men's Health diabetes mellitus erectile dysfunction nitric oxide red light relaxation |
| title | The Effects of a Red-Light Controllable Nitric Oxide Donor, NORD-1, on Erectile Dysfunction in Rats with Streptozotocin Induced Diabetes Mellitus |
| title_full | The Effects of a Red-Light Controllable Nitric Oxide Donor, NORD-1, on Erectile Dysfunction in Rats with Streptozotocin Induced Diabetes Mellitus |
| title_fullStr | The Effects of a Red-Light Controllable Nitric Oxide Donor, NORD-1, on Erectile Dysfunction in Rats with Streptozotocin Induced Diabetes Mellitus |
| title_full_unstemmed | The Effects of a Red-Light Controllable Nitric Oxide Donor, NORD-1, on Erectile Dysfunction in Rats with Streptozotocin Induced Diabetes Mellitus |
| title_short | The Effects of a Red-Light Controllable Nitric Oxide Donor, NORD-1, on Erectile Dysfunction in Rats with Streptozotocin Induced Diabetes Mellitus |
| title_sort | effects of a red light controllable nitric oxide donor nord 1 on erectile dysfunction in rats with streptozotocin induced diabetes mellitus |
| topic | diabetes mellitus erectile dysfunction nitric oxide red light relaxation |
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