Extracellular matrix shapes cancer stem cell behavior in breast cancer: a mini review
Today, cancer has become one of the leading global tragedies. It occurs when a small number of cells in the body mutate, causing some of them to evade the body’s immune system and proliferate uncontrollably. Even more irritating is the fact that patients with cancers frequently relapse after convent...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1503021/full |
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| author | Lei Li Lei Li Yidan Tang Ling Qiu Ling Qiu Zhengrui Li Ruo Wang Ruo Wang |
| author_facet | Lei Li Lei Li Yidan Tang Ling Qiu Ling Qiu Zhengrui Li Ruo Wang Ruo Wang |
| author_sort | Lei Li |
| collection | DOAJ |
| description | Today, cancer has become one of the leading global tragedies. It occurs when a small number of cells in the body mutate, causing some of them to evade the body’s immune system and proliferate uncontrollably. Even more irritating is the fact that patients with cancers frequently relapse after conventional chemotherapy and radiotherapy, leading to additional suffering. Scientists thereby presume that cancer stem cells (CSCs) are the underlying cause of metastasis and recurrence. In recent years, it was shown that not only can chemotherapy and radiotherapy underperform in the treatment of breast cancer, but they can also increase the number of breast cancer stem cells (BCSCs) that transform regular breast cancer cells into their own population. Such data somewhat support the aforementioned hypothesis. Meanwhile, our understanding of the extracellular matrix (ECM) has changed considerably over the last decade. A lot of studies have bit by bit complemented human knowledge regarding how the ECM greatly shapes the behaviors of BCSCs. In this review, we highlighted the influence on BCSCs exerted by different critical components and biochemical properties of ECM. |
| format | Article |
| id | doaj-art-9a0e032c60ce4d5da3d7ac4d044dbbcf |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-9a0e032c60ce4d5da3d7ac4d044dbbcf2025-01-09T06:10:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15030211503021Extracellular matrix shapes cancer stem cell behavior in breast cancer: a mini reviewLei Li0Lei Li1Yidan Tang2Ling Qiu3Ling Qiu4Zhengrui Li5Ruo Wang6Ruo Wang7Department of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, ChinaState Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, ChinaFaculty of Medicine, University of Debrecen, Debrecen, HungaryDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, ChinaState Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, ChinaShanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShengli Clinical Medical College of Fujian Medical University, Department of Breast Surgery, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, ChinaToday, cancer has become one of the leading global tragedies. It occurs when a small number of cells in the body mutate, causing some of them to evade the body’s immune system and proliferate uncontrollably. Even more irritating is the fact that patients with cancers frequently relapse after conventional chemotherapy and radiotherapy, leading to additional suffering. Scientists thereby presume that cancer stem cells (CSCs) are the underlying cause of metastasis and recurrence. In recent years, it was shown that not only can chemotherapy and radiotherapy underperform in the treatment of breast cancer, but they can also increase the number of breast cancer stem cells (BCSCs) that transform regular breast cancer cells into their own population. Such data somewhat support the aforementioned hypothesis. Meanwhile, our understanding of the extracellular matrix (ECM) has changed considerably over the last decade. A lot of studies have bit by bit complemented human knowledge regarding how the ECM greatly shapes the behaviors of BCSCs. In this review, we highlighted the influence on BCSCs exerted by different critical components and biochemical properties of ECM.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1503021/fullextracellular matrixcancer stem cellsbreast cancerECMBCSCs |
| spellingShingle | Lei Li Lei Li Yidan Tang Ling Qiu Ling Qiu Zhengrui Li Ruo Wang Ruo Wang Extracellular matrix shapes cancer stem cell behavior in breast cancer: a mini review Frontiers in Immunology extracellular matrix cancer stem cells breast cancer ECM BCSCs |
| title | Extracellular matrix shapes cancer stem cell behavior in breast cancer: a mini review |
| title_full | Extracellular matrix shapes cancer stem cell behavior in breast cancer: a mini review |
| title_fullStr | Extracellular matrix shapes cancer stem cell behavior in breast cancer: a mini review |
| title_full_unstemmed | Extracellular matrix shapes cancer stem cell behavior in breast cancer: a mini review |
| title_short | Extracellular matrix shapes cancer stem cell behavior in breast cancer: a mini review |
| title_sort | extracellular matrix shapes cancer stem cell behavior in breast cancer a mini review |
| topic | extracellular matrix cancer stem cells breast cancer ECM BCSCs |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1503021/full |
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