Effects of paternal ionizing radiation exposure on fertility and offspring's health
Abstract Purpose The intergenerational effects of ionizing radiation remain controversial. Extensive insights have been revealed for DNA mutations and cancer incidence in progeny, yet many of these results were obtained by immediate post‐radiation mating. However, conception at short times after rad...
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| Format: | Article |
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Wiley
2024-01-01
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| Series: | Reproductive Medicine and Biology |
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| Online Access: | https://doi.org/10.1002/rmb2.12567 |
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| author | Jiaqun Li Juan Liu Yanye Zhang Hong Qiu Junyan Zheng Jinglei Xue Jiani Jin Feida Ni Chunxi Zhang Chuan Chen Xiao Sun Huiquan Wang Dan Zhang |
| author_facet | Jiaqun Li Juan Liu Yanye Zhang Hong Qiu Junyan Zheng Jinglei Xue Jiani Jin Feida Ni Chunxi Zhang Chuan Chen Xiao Sun Huiquan Wang Dan Zhang |
| author_sort | Jiaqun Li |
| collection | DOAJ |
| description | Abstract Purpose The intergenerational effects of ionizing radiation remain controversial. Extensive insights have been revealed for DNA mutations and cancer incidence in progeny, yet many of these results were obtained by immediate post‐radiation mating. However, conception at short times after radiation exposure is likely to be avoided. After a long period of fertility recovery, whether unexposed sperm derived from exposed spermatogonia would challenge the health of the offspring is not yet clearly demonstrated. Methods Ten‐week‐old C57BL/6J males underwent whole‐body acute γ irradiation at 0 and 6.4 Gy. Testes and sperm were collected at different times after radiation to examine reproductive changes. The reproductive, metabolic, and neurodevelopmental parameters were measured in the offspring of controls and the offspring derived from irradiated undifferentiated spermatogonia. Results Paternal fertility was lost after acute 6.4 Gy γ radiation and recovered at 10–11 weeks post irradiation in mice. The reproductive, metabolic, and neurodevelopmental health of offspring born to irradiated undifferentiated spermatogonia were comparable to those of controls. Conclusion The male mice could have healthy offspring after recovery from the damage caused by ionizing radiation. |
| format | Article |
| id | doaj-art-99fb6126bc5d4286b6ac328b64cfe4e1 |
| institution | Kabale University |
| issn | 1445-5781 1447-0578 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj-art-99fb6126bc5d4286b6ac328b64cfe4e12024-12-20T06:08:37ZengWileyReproductive Medicine and Biology1445-57811447-05782024-01-01231n/an/a10.1002/rmb2.12567Effects of paternal ionizing radiation exposure on fertility and offspring's healthJiaqun Li0Juan Liu1Yanye Zhang2Hong Qiu3Junyan Zheng4Jinglei Xue5Jiani Jin6Feida Ni7Chunxi Zhang8Chuan Chen9Xiao Sun10Huiquan Wang11Dan Zhang12Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital Zhejiang University School of Medicine Zhejiang ChinaKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital Zhejiang University School of Medicine Zhejiang ChinaKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital Zhejiang University School of Medicine Zhejiang ChinaZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology Life Sciences Institute, Zhejiang University Hangzhou ChinaKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital Zhejiang University School of Medicine Zhejiang ChinaKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital Zhejiang University School of Medicine Zhejiang ChinaKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital Zhejiang University School of Medicine Zhejiang ChinaKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital Zhejiang University School of Medicine Zhejiang ChinaKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital Zhejiang University School of Medicine Zhejiang ChinaKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital Zhejiang University School of Medicine Zhejiang ChinaKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital Zhejiang University School of Medicine Zhejiang ChinaThe School of Aeronautics and Astronautics Zhejiang University Hangzhou ChinaKey Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital Zhejiang University School of Medicine Zhejiang ChinaAbstract Purpose The intergenerational effects of ionizing radiation remain controversial. Extensive insights have been revealed for DNA mutations and cancer incidence in progeny, yet many of these results were obtained by immediate post‐radiation mating. However, conception at short times after radiation exposure is likely to be avoided. After a long period of fertility recovery, whether unexposed sperm derived from exposed spermatogonia would challenge the health of the offspring is not yet clearly demonstrated. Methods Ten‐week‐old C57BL/6J males underwent whole‐body acute γ irradiation at 0 and 6.4 Gy. Testes and sperm were collected at different times after radiation to examine reproductive changes. The reproductive, metabolic, and neurodevelopmental parameters were measured in the offspring of controls and the offspring derived from irradiated undifferentiated spermatogonia. Results Paternal fertility was lost after acute 6.4 Gy γ radiation and recovered at 10–11 weeks post irradiation in mice. The reproductive, metabolic, and neurodevelopmental health of offspring born to irradiated undifferentiated spermatogonia were comparable to those of controls. Conclusion The male mice could have healthy offspring after recovery from the damage caused by ionizing radiation.https://doi.org/10.1002/rmb2.12567fertility recoveryintergenerational effectsionizing radiationoffspringundifferentiated spermatogonia |
| spellingShingle | Jiaqun Li Juan Liu Yanye Zhang Hong Qiu Junyan Zheng Jinglei Xue Jiani Jin Feida Ni Chunxi Zhang Chuan Chen Xiao Sun Huiquan Wang Dan Zhang Effects of paternal ionizing radiation exposure on fertility and offspring's health Reproductive Medicine and Biology fertility recovery intergenerational effects ionizing radiation offspring undifferentiated spermatogonia |
| title | Effects of paternal ionizing radiation exposure on fertility and offspring's health |
| title_full | Effects of paternal ionizing radiation exposure on fertility and offspring's health |
| title_fullStr | Effects of paternal ionizing radiation exposure on fertility and offspring's health |
| title_full_unstemmed | Effects of paternal ionizing radiation exposure on fertility and offspring's health |
| title_short | Effects of paternal ionizing radiation exposure on fertility and offspring's health |
| title_sort | effects of paternal ionizing radiation exposure on fertility and offspring s health |
| topic | fertility recovery intergenerational effects ionizing radiation offspring undifferentiated spermatogonia |
| url | https://doi.org/10.1002/rmb2.12567 |
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