Determination of embryotoxic and teratogenic effects of flunixin meglumine given early stage in ovo
<b>Aim: </b>The aim of this study was to determine embryotoxic and teratogenic effects of flunixin meglumine (FM), a nonsteroid anti-inflammatory drug used for analgesic and antipyretic, given early stage in ovo.<p> <b>Material and Methods:</b> For this purpose, 300 chi...
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1144 |
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| author | Murat Öznurlu Yasemin Öznurlu |
| author_facet | Murat Öznurlu Yasemin Öznurlu |
| author_sort | Murat Öznurlu |
| collection | DOAJ |
| description | <b>Aim: </b>The aim of this study was to determine embryotoxic
and teratogenic effects of flunixin meglumine (FM), a nonsteroid
anti-inflammatory drug used for analgesic and antipyretic,
given early stage in ovo.<p>
<b>Material and Methods:</b> For this purpose, 300 chicken eggs
were used. The eggs were divided into the groups as follows:
1. Group: Control group, 2. Group: 2.2 mg/kg FM group, 3.
Group: 5.5 mg/kg FM group and 4 Group: 11 mg/kg FM group.
Test solutions were injected via air-sac just prior to the
settlement of the eggs into the incubator. Eggs from each group
were opened on various days of the incubation and developmental
stages of embryos were determined according
to the Hamburger-Hamilton scale. Also, malformation types,
both live and relative embryo weights and crown-rump
lengths (CRL) were determined.<p>
<b>Results:</b> The mortality in the treated FM groups was found
to be significantly (P<0.05) higher than control. The live and
relative embryo weights and embryo CRL values of the FM
groups were significantly lower than that of the control group
(P<0.05). In the treated FM groups showed embryonic
growth retardation and various structural abnormalities.<p>
It may be stated administration of FM cause teratogenity in
mammalian species when administered in pregnancy period. |
| format | Article |
| id | doaj-art-99e4cd839ab8472ab3abe98ba7dd98cf |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-99e4cd839ab8472ab3abe98ba7dd98cf2025-01-03T01:36:16ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19533242602671144Determination of embryotoxic and teratogenic effects of flunixin meglumine given early stage in ovoMurat Öznurlu0Yasemin Öznurlu1Selçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Kampüs, Konya, Türkiye<b>Aim: </b>The aim of this study was to determine embryotoxic and teratogenic effects of flunixin meglumine (FM), a nonsteroid anti-inflammatory drug used for analgesic and antipyretic, given early stage in ovo.<p> <b>Material and Methods:</b> For this purpose, 300 chicken eggs were used. The eggs were divided into the groups as follows: 1. Group: Control group, 2. Group: 2.2 mg/kg FM group, 3. Group: 5.5 mg/kg FM group and 4 Group: 11 mg/kg FM group. Test solutions were injected via air-sac just prior to the settlement of the eggs into the incubator. Eggs from each group were opened on various days of the incubation and developmental stages of embryos were determined according to the Hamburger-Hamilton scale. Also, malformation types, both live and relative embryo weights and crown-rump lengths (CRL) were determined.<p> <b>Results:</b> The mortality in the treated FM groups was found to be significantly (P<0.05) higher than control. The live and relative embryo weights and embryo CRL values of the FM groups were significantly lower than that of the control group (P<0.05). In the treated FM groups showed embryonic growth retardation and various structural abnormalities.<p> It may be stated administration of FM cause teratogenity in mammalian species when administered in pregnancy period.http://eurasianjvetsci.org/pdf.php3?id=1144embryotoxicityflunixin megluminechick embryo |
| spellingShingle | Murat Öznurlu Yasemin Öznurlu Determination of embryotoxic and teratogenic effects of flunixin meglumine given early stage in ovo Eurasian Journal of Veterinary Sciences embryotoxicity flunixin meglumine chick embryo |
| title | Determination of embryotoxic and teratogenic effects of flunixin meglumine given early stage in ovo |
| title_full | Determination of embryotoxic and teratogenic effects of flunixin meglumine given early stage in ovo |
| title_fullStr | Determination of embryotoxic and teratogenic effects of flunixin meglumine given early stage in ovo |
| title_full_unstemmed | Determination of embryotoxic and teratogenic effects of flunixin meglumine given early stage in ovo |
| title_short | Determination of embryotoxic and teratogenic effects of flunixin meglumine given early stage in ovo |
| title_sort | determination of embryotoxic and teratogenic effects of flunixin meglumine given early stage in ovo |
| topic | embryotoxicity flunixin meglumine chick embryo |
| url | http://eurasianjvetsci.org/pdf.php3?id=1144 |
| work_keys_str_mv | AT muratoznurlu determinationofembryotoxicandteratogeniceffectsofflunixinmegluminegivenearlystageinovo AT yaseminoznurlu determinationofembryotoxicandteratogeniceffectsofflunixinmegluminegivenearlystageinovo |