Determination of embryotoxic and teratogenic effects of flunixin meglumine given early stage in ovo
<b>Aim: </b>The aim of this study was to determine embryotoxic and teratogenic effects of flunixin meglumine (FM), a nonsteroid anti-inflammatory drug used for analgesic and antipyretic, given early stage in ovo.<p> <b>Material and Methods:</b> For this purpose, 300 chi...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1144 |
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| Summary: | <b>Aim: </b>The aim of this study was to determine embryotoxic
and teratogenic effects of flunixin meglumine (FM), a nonsteroid
anti-inflammatory drug used for analgesic and antipyretic,
given early stage in ovo.<p>
<b>Material and Methods:</b> For this purpose, 300 chicken eggs
were used. The eggs were divided into the groups as follows:
1. Group: Control group, 2. Group: 2.2 mg/kg FM group, 3.
Group: 5.5 mg/kg FM group and 4 Group: 11 mg/kg FM group.
Test solutions were injected via air-sac just prior to the
settlement of the eggs into the incubator. Eggs from each group
were opened on various days of the incubation and developmental
stages of embryos were determined according
to the Hamburger-Hamilton scale. Also, malformation types,
both live and relative embryo weights and crown-rump
lengths (CRL) were determined.<p>
<b>Results:</b> The mortality in the treated FM groups was found
to be significantly (P<0.05) higher than control. The live and
relative embryo weights and embryo CRL values of the FM
groups were significantly lower than that of the control group
(P<0.05). In the treated FM groups showed embryonic
growth retardation and various structural abnormalities.<p>
It may be stated administration of FM cause teratogenity in
mammalian species when administered in pregnancy period. |
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| ISSN: | 1309-6958 2146-1953 |