Recombinant SAG2A Protein from <i>Toxoplasma gondii</i> Modulates Immune Profile and Induces Metabolic Changes Associated with Reduced Tachyzoite Infection in Peritoneal Exudate Cells from Susceptible C57BL/6 Mice

Recombinant SAG2A Protein from <i>Toxoplasma gondii</i> Modulates Immune Profile and Induces Metabolic Changes Associated with Reduced Tachyzoite Infection in Peritoneal Exudate Cells from Susceptible C57BL/6 Mice

Toxoplasmosis is a neglected disease that represents a significant public health problem. The antigenic profile of <i>T. gondii</i> is complex, and the immune response can lead to either susceptibility or resistance. Some antigens, such as surface antigen glycoprotein (SAG), are expresse...

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Main Authors: Thaíse Anne Rocha dos Santos, Mário Cézar de Oliveira, Edson Mario de Andrade Silva, Uener Ribeiro dos Santos, Monaliza Macêdo Ferreira, Ana Luísa Corrêa Soares, Neide Maria Silva, Tiago Antônio de Oliveira Mendes, Jamilly Azevedo Leal-Sena, Jair Pereira da Cunha-Júnior, Tiago Wilson Patriarca Mineo, José Roberto Mineo, Érica Araújo Mendes, Jane Lima-Santos, Carlos Priminho Pirovani
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Microorganisms
Subjects:
<i>Toxoplasma gondii</i>
macrophages
rSAG2A
cytokine
inflammation
Online Access:https://www.mdpi.com/2076-2607/12/11/2366
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