Exosome-transmitted HSPA9 facilitates bortezomib resistance by targeting TRIP13/USP1 signaling in multiple myeloma

Exosome-transmitted HSPA9 facilitates bortezomib resistance by targeting TRIP13/USP1 signaling in multiple myeloma

Abstract Background Resistance to the proteasome inhibitor bortezomib (BTZ) poses a formidable therapeutic challenge in multiple myeloma (MM). Our study aims to analyze the mechanism by which exosomes heat shock 70 kDa protein 9 (HSPA9) secreted by BTZ-resistant MM cells disseminate resistance to BT...

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Bibliographic Details
Main Authors: Min Shi, Na Shen, Xiangyu Liu, Jiapei Yu, Xuxing Shen, Ying Chen, Yuan Xia, Lijuan Chen
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cell Communication and Signaling
Subjects:
Exosome
HSPA9
Multiple myeloma
USP1
TRIP13
Online Access:https://doi.org/10.1186/s12964-025-02158-3
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