Transitioning from NAFLD to MAFLD and MASLD: the toxic relationship with alcohol consumption
Alcohol is a well-known toxic etiologic factor for liver injury. Metabolic substrates of alcohol (especially acetaldehyde) have a major responsibility and genetic susceptibility, alterations in microbiota and immune system are important co-factors for this injury. Major injury in liver is hepatocell...
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| Language: | English |
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Open Exploration Publishing Inc.
2025-01-01
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| Series: | Exploration of Medicine |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A1001273/1001273.pdf |
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| author | Mubin Ozercan Ahmed Tawheed Mohamed El-Kassas |
| author_facet | Mubin Ozercan Ahmed Tawheed Mohamed El-Kassas |
| author_sort | Mubin Ozercan |
| collection | DOAJ |
| description | Alcohol is a well-known toxic etiologic factor for liver injury. Metabolic substrates of alcohol (especially acetaldehyde) have a major responsibility and genetic susceptibility, alterations in microbiota and immune system are important co-factors for this injury. Major injury in liver is hepatocellular lipid accumulation. Therefore the relationship between non-alcoholic and alcoholic fatty liver diseases should have been defined clearly. Recently two major liver committees adopted new terminologies such as metabolic-associated fatty liver disease (MAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-related liver disease (MetALD), and alcoholic liver disease (ALD) instead of non-alcoholic fatty liver disease (NAFLD). These terminologies were based on the effects of metabolic syndrome on liver. Alcohol consumption was defined differently according to these nomenclatures. MAFLD defined alcohol intake (regardless of amount) as “dual etiology fatty liver disease” and the Delphi consensus defined MASLD, MetALD, or ALD according to daily consumption of alcohol amount. |
| format | Article |
| id | doaj-art-99b87ad433a241e0a4c30750e3b7208d |
| institution | Kabale University |
| issn | 2692-3106 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Medicine |
| spelling | doaj-art-99b87ad433a241e0a4c30750e3b7208d2025-01-14T07:15:11ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062025-01-016100127310.37349/emed.2025.1001273Transitioning from NAFLD to MAFLD and MASLD: the toxic relationship with alcohol consumptionMubin Ozercan0https://orcid.org/0000-0002-6968-7838Ahmed Tawheed1https://orcid.org/0000-0002-9382-8733Mohamed El-Kassas2https://orcid.org/0000-0002-3396-6894Department of Gastroenterology, Faculty of Medicine, Firat University, Elazig 23119, TurkeyEndemic Medicine Department, Faculty of Medicine, Helwan University, Cairo 11795, EgyptEndemic Medicine Department, Faculty of Medicine, Helwan University, Cairo 11795, Egypt; Liver Disease Research Center, College of Medicine, King Saud University, Riyadh 7805, Saudi ArabiaAlcohol is a well-known toxic etiologic factor for liver injury. Metabolic substrates of alcohol (especially acetaldehyde) have a major responsibility and genetic susceptibility, alterations in microbiota and immune system are important co-factors for this injury. Major injury in liver is hepatocellular lipid accumulation. Therefore the relationship between non-alcoholic and alcoholic fatty liver diseases should have been defined clearly. Recently two major liver committees adopted new terminologies such as metabolic-associated fatty liver disease (MAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-related liver disease (MetALD), and alcoholic liver disease (ALD) instead of non-alcoholic fatty liver disease (NAFLD). These terminologies were based on the effects of metabolic syndrome on liver. Alcohol consumption was defined differently according to these nomenclatures. MAFLD defined alcohol intake (regardless of amount) as “dual etiology fatty liver disease” and the Delphi consensus defined MASLD, MetALD, or ALD according to daily consumption of alcohol amount.https://www.explorationpub.com/uploads/Article/A1001273/1001273.pdfmetabolic dysfunction-associated steatotic liver diseasenon-alcoholic fatty liver diseasealcoholic liver diseasemetabolic dysfunction-associated fatty liver diseasealcohol consumption |
| spellingShingle | Mubin Ozercan Ahmed Tawheed Mohamed El-Kassas Transitioning from NAFLD to MAFLD and MASLD: the toxic relationship with alcohol consumption Exploration of Medicine metabolic dysfunction-associated steatotic liver disease non-alcoholic fatty liver disease alcoholic liver disease metabolic dysfunction-associated fatty liver disease alcohol consumption |
| title | Transitioning from NAFLD to MAFLD and MASLD: the toxic relationship with alcohol consumption |
| title_full | Transitioning from NAFLD to MAFLD and MASLD: the toxic relationship with alcohol consumption |
| title_fullStr | Transitioning from NAFLD to MAFLD and MASLD: the toxic relationship with alcohol consumption |
| title_full_unstemmed | Transitioning from NAFLD to MAFLD and MASLD: the toxic relationship with alcohol consumption |
| title_short | Transitioning from NAFLD to MAFLD and MASLD: the toxic relationship with alcohol consumption |
| title_sort | transitioning from nafld to mafld and masld the toxic relationship with alcohol consumption |
| topic | metabolic dysfunction-associated steatotic liver disease non-alcoholic fatty liver disease alcoholic liver disease metabolic dysfunction-associated fatty liver disease alcohol consumption |
| url | https://www.explorationpub.com/uploads/Article/A1001273/1001273.pdf |
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