Safety analysis of brachial artery sheath removal after heparin reversal with a half dose of protamine after percutaneous coronary intervention: a single-center experience
AimTo evaluate the safety of brachial artery (BA) sheath removal after heparin neutralization with a half dose of protamine immediately after percutaneous coronary intervention (PCI).MethodsThe clinical data of 209 consecutive patients who underwent PCI through the BA at Fu Wai Hospital between Sept...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1479506/full |
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| author | Huanhuan Wang Cheng Cui Dan Liu Hongmei Liu Tao Tian Minghao Liu Bo Zhang Tongqiang Zou Zhan Gao Lijian Gao Haibo Liu |
| author_facet | Huanhuan Wang Cheng Cui Dan Liu Hongmei Liu Tao Tian Minghao Liu Bo Zhang Tongqiang Zou Zhan Gao Lijian Gao Haibo Liu |
| author_sort | Huanhuan Wang |
| collection | DOAJ |
| description | AimTo evaluate the safety of brachial artery (BA) sheath removal after heparin neutralization with a half dose of protamine immediately after percutaneous coronary intervention (PCI).MethodsThe clinical data of 209 consecutive patients who underwent PCI through the BA at Fu Wai Hospital between September 2019 and June 2024 were retrospectively collected. In group I, the brachial sheath was removed 4 h after the PCI procedure. In group II, circulating heparin was neutralized with a half dose of protamine sulfate, and the brachial sheath was removed immediately after the procedure.ResultsThere were no cases of acute stent thrombosis, nonfatal myocardial infarction or in-hospital mortality in either group. In group II, there were two cases of pseudoaneurysm, one of which was transfer to surgery and the other was manually compressed. No severe puncture site-related bleeding occurred. The levels of hemoglobin were similar between the two groups before and after the PCI procedure (p > 0.05).ConclusionsThe BA sheath can be safely removed immediately after PCI by neutralizing heparin with a half dose of protamine. But we still need to be vigilant about the occurrence of pseudoaneurysms. |
| format | Article |
| id | doaj-art-998367ff9d624a3daef1d4114e5ba277 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-998367ff9d624a3daef1d4114e5ba2772025-01-15T14:44:08ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011110.3389/fcvm.2024.14795061479506Safety analysis of brachial artery sheath removal after heparin reversal with a half dose of protamine after percutaneous coronary intervention: a single-center experienceHuanhuan Wang0Cheng Cui1Dan Liu2Hongmei Liu3Tao Tian4Minghao Liu5Bo Zhang6Tongqiang Zou7Zhan Gao8Lijian Gao9Haibo Liu10Department of Cardiology, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, Shihezi People’s Hospital, The Third Affiliated Hospital of Shihezi University School of Medicine, Xinjiang, ChinaDepartment of Cardiology, Shihezi People’s Hospital, The Third Affiliated Hospital of Shihezi University School of Medicine, Xinjiang, ChinaDepartment of Cardiology, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, Yunnan Fuwai Cardiovascular Hospital, Kunming, Yunnan, ChinaDepartment of Cardiology, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Cardiology, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaAimTo evaluate the safety of brachial artery (BA) sheath removal after heparin neutralization with a half dose of protamine immediately after percutaneous coronary intervention (PCI).MethodsThe clinical data of 209 consecutive patients who underwent PCI through the BA at Fu Wai Hospital between September 2019 and June 2024 were retrospectively collected. In group I, the brachial sheath was removed 4 h after the PCI procedure. In group II, circulating heparin was neutralized with a half dose of protamine sulfate, and the brachial sheath was removed immediately after the procedure.ResultsThere were no cases of acute stent thrombosis, nonfatal myocardial infarction or in-hospital mortality in either group. In group II, there were two cases of pseudoaneurysm, one of which was transfer to surgery and the other was manually compressed. No severe puncture site-related bleeding occurred. The levels of hemoglobin were similar between the two groups before and after the PCI procedure (p > 0.05).ConclusionsThe BA sheath can be safely removed immediately after PCI by neutralizing heparin with a half dose of protamine. But we still need to be vigilant about the occurrence of pseudoaneurysms.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1479506/fullbrachial arteryheparinprotaminepercutaneous coronary interventionsafety |
| spellingShingle | Huanhuan Wang Cheng Cui Dan Liu Hongmei Liu Tao Tian Minghao Liu Bo Zhang Tongqiang Zou Zhan Gao Lijian Gao Haibo Liu Safety analysis of brachial artery sheath removal after heparin reversal with a half dose of protamine after percutaneous coronary intervention: a single-center experience Frontiers in Cardiovascular Medicine brachial artery heparin protamine percutaneous coronary intervention safety |
| title | Safety analysis of brachial artery sheath removal after heparin reversal with a half dose of protamine after percutaneous coronary intervention: a single-center experience |
| title_full | Safety analysis of brachial artery sheath removal after heparin reversal with a half dose of protamine after percutaneous coronary intervention: a single-center experience |
| title_fullStr | Safety analysis of brachial artery sheath removal after heparin reversal with a half dose of protamine after percutaneous coronary intervention: a single-center experience |
| title_full_unstemmed | Safety analysis of brachial artery sheath removal after heparin reversal with a half dose of protamine after percutaneous coronary intervention: a single-center experience |
| title_short | Safety analysis of brachial artery sheath removal after heparin reversal with a half dose of protamine after percutaneous coronary intervention: a single-center experience |
| title_sort | safety analysis of brachial artery sheath removal after heparin reversal with a half dose of protamine after percutaneous coronary intervention a single center experience |
| topic | brachial artery heparin protamine percutaneous coronary intervention safety |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1479506/full |
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