Novel gene manipulation approaches to unlock the existing bottlenecks of CAR-NK cell therapy

Novel gene manipulation approaches to unlock the existing bottlenecks of CAR-NK cell therapy

Currently, CAR-T cell therapy is known as an efficacious treatment for patients with relapsed/refractory hematologic malignancies. Nonetheless, this method faces several bottlenecks, including low efficacy for solid tumors, lethal adverse effects, high cost of autologous products, and the risk of Gv...

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Bibliographic Details
Main Authors: Fatemeh Dehghan, Yekta Metanat, Mandana Askarizadeh, Ehsan Ahmadi, Vahid Moradi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CAR-NK
chimeric antigen receptor (CAR)
genetic engineering
gene editing
immunotherapy
CRISPR/Cas9
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1511931/full
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