Malignant Transformation of Normal Oral Tissue to Dysplasia and Early Oral Squamous Cell Carcinoma: An In Silico Transcriptomics Approach
Conclusion: This study identified vital genes, pathways, and prognostic markers involved in the malignant transformation from normal oral tissue to OPL and primary OSCC, providing insights for early diagnosis and targeted therapy development. Cross-validation with an independent RNA-seq dataset and...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2024/6260651 |
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| _version_ | 1846143956858961920 |
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| author | Shokoofeh Jamshidi Matina Tavangar Setareh Shojaei Amir Taherkhani |
| author_facet | Shokoofeh Jamshidi Matina Tavangar Setareh Shojaei Amir Taherkhani |
| author_sort | Shokoofeh Jamshidi |
| collection | DOAJ |
| description | Conclusion: This study identified vital genes, pathways, and prognostic markers involved in the malignant transformation from normal oral tissue to OPL and primary OSCC, providing insights for early diagnosis and targeted therapy development. Cross-validation with an independent RNA-seq dataset and immunohistochemistry reinforced the findings, supporting the robustness of the identified molecular signatures. |
| format | Article |
| id | doaj-art-99357105093c43899f8e204109b559cf |
| institution | Kabale University |
| issn | 2210-7185 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-99357105093c43899f8e204109b559cf2024-12-02T09:18:05ZengWileyAnalytical Cellular Pathology2210-71852024-01-01202410.1155/2024/6260651Malignant Transformation of Normal Oral Tissue to Dysplasia and Early Oral Squamous Cell Carcinoma: An In Silico Transcriptomics ApproachShokoofeh Jamshidi0Matina Tavangar1Setareh Shojaei2Amir Taherkhani3Department of Oral and Maxillofacial PathologyDepartment of Oral and Maxillofacial PathologyDepartment of Oral and Maxillofacial PathologyResearch Center for Molecular MedicineConclusion: This study identified vital genes, pathways, and prognostic markers involved in the malignant transformation from normal oral tissue to OPL and primary OSCC, providing insights for early diagnosis and targeted therapy development. Cross-validation with an independent RNA-seq dataset and immunohistochemistry reinforced the findings, supporting the robustness of the identified molecular signatures.http://dx.doi.org/10.1155/2024/6260651 |
| spellingShingle | Shokoofeh Jamshidi Matina Tavangar Setareh Shojaei Amir Taherkhani Malignant Transformation of Normal Oral Tissue to Dysplasia and Early Oral Squamous Cell Carcinoma: An In Silico Transcriptomics Approach Analytical Cellular Pathology |
| title | Malignant Transformation of Normal Oral Tissue to Dysplasia and Early Oral Squamous Cell Carcinoma: An In Silico Transcriptomics Approach |
| title_full | Malignant Transformation of Normal Oral Tissue to Dysplasia and Early Oral Squamous Cell Carcinoma: An In Silico Transcriptomics Approach |
| title_fullStr | Malignant Transformation of Normal Oral Tissue to Dysplasia and Early Oral Squamous Cell Carcinoma: An In Silico Transcriptomics Approach |
| title_full_unstemmed | Malignant Transformation of Normal Oral Tissue to Dysplasia and Early Oral Squamous Cell Carcinoma: An In Silico Transcriptomics Approach |
| title_short | Malignant Transformation of Normal Oral Tissue to Dysplasia and Early Oral Squamous Cell Carcinoma: An In Silico Transcriptomics Approach |
| title_sort | malignant transformation of normal oral tissue to dysplasia and early oral squamous cell carcinoma an in silico transcriptomics approach |
| url | http://dx.doi.org/10.1155/2024/6260651 |
| work_keys_str_mv | AT shokoofehjamshidi malignanttransformationofnormaloraltissuetodysplasiaandearlyoralsquamouscellcarcinomaaninsilicotranscriptomicsapproach AT matinatavangar malignanttransformationofnormaloraltissuetodysplasiaandearlyoralsquamouscellcarcinomaaninsilicotranscriptomicsapproach AT setarehshojaei malignanttransformationofnormaloraltissuetodysplasiaandearlyoralsquamouscellcarcinomaaninsilicotranscriptomicsapproach AT amirtaherkhani malignanttransformationofnormaloraltissuetodysplasiaandearlyoralsquamouscellcarcinomaaninsilicotranscriptomicsapproach |