A Novel, Cell-Compatible Hyaluronidase Activity Assay Identifies Dextran Sulfates and Other Sulfated Polymeric Hydrocarbons as Potent Inhibitors for CEMIP

A Novel, Cell-Compatible Hyaluronidase Activity Assay Identifies Dextran Sulfates and Other Sulfated Polymeric Hydrocarbons as Potent Inhibitors for CEMIP

Hyaluronan (HA) levels are dynamically regulated homeostatically through biosynthesis and degradation. HA homeostasis is often perturbed under disease conditions. HA degradation products are thought to contribute to disease pathology. The hyaluronidase CEMIP requires the presence of living cells for...

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Bibliographic Details
Main Authors: Anja Schmaus, Sofia Spataro, Paul Sallmann, Stephanie Möller, Leonardo Scapozza, Marco Prunotto, Jonathan P. Sleeman
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
CEMIP
HYBID
hyaluronidase
hyaluronan
dextran sulfate
heparin
Online Access:https://www.mdpi.com/2073-4409/14/2/101
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