Mediating role of sleep quality in the relationship between diabetes mellitus and visual function: a cross-sectional study
Abstract Diabetes mellitus (DM) is a major global health concern associated with complications that significantly impair quality of life. Among these, the impact of DM on visual function and the underlying mechanisms, particularly the role of sleep quality, remain insufficiently understood. This cro...
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| Format: | Article |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-06641-2 |
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| author | Yingrui Yang Xiaoting Pei Jiali Sun Mengting Xia Lina Tian Yanxia Kang Zhijie Li |
| author_facet | Yingrui Yang Xiaoting Pei Jiali Sun Mengting Xia Lina Tian Yanxia Kang Zhijie Li |
| author_sort | Yingrui Yang |
| collection | DOAJ |
| description | Abstract Diabetes mellitus (DM) is a major global health concern associated with complications that significantly impair quality of life. Among these, the impact of DM on visual function and the underlying mechanisms, particularly the role of sleep quality, remain insufficiently understood. This cross-sectional study recruited 629 participants from Henan Provincial People’s Hospital to examine the relationships among DM, sleep quality, and visual function. Visual function was assessed using the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25), while sleep quality was evaluated with the Pittsburgh Sleep Quality Index (PSQI). Compared to non-diabetic controls, individuals with DM exhibited significantly poorer visual function and sleep quality. Path analysis further revealed that sleep quality played a significant mediating role in the relationship between DM and visual function, accounting for 42.2% of the total effect. Subgroup analyses indicated that female and elderly patients with DM were more susceptible to the influence of sleep disturbances on visual outcomes. These findings underscore the critical role of sleep quality in diabetes-related visual impairment and highlight the importance of incorporating routine sleep assessments and targeted interventions into diabetes management to help preserve visual function and improve overall quality of life in diabetic populations. |
| format | Article |
| id | doaj-art-98b4c5ccd3494325b10f8de743e15c4e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-98b4c5ccd3494325b10f8de743e15c4e2025-08-20T03:45:26ZengNature PortfolioScientific Reports2045-23222025-07-0115111310.1038/s41598-025-06641-2Mediating role of sleep quality in the relationship between diabetes mellitus and visual function: a cross-sectional studyYingrui Yang0Xiaoting Pei1Jiali Sun2Mengting Xia3Lina Tian4Yanxia Kang5Zhijie Li6Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People’s Hospital, Henan Eye Institute, People’s Hospital of Zhengzhou UniversityHenan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People’s Hospital, Henan Eye Institute, People’s Hospital of Zhengzhou UniversityHenan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People’s Hospital, Henan Eye Institute, People’s Hospital of Zhengzhou UniversityHenan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People’s Hospital, Henan Eye Institute, People’s Hospital of Zhengzhou UniversityHenan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People’s Hospital, Henan Eye Institute, People’s Hospital of Zhengzhou UniversityHenan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People’s Hospital, Henan Eye Institute, People’s Hospital of Zhengzhou UniversityHenan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People’s Hospital, Henan Eye Institute, People’s Hospital of Zhengzhou UniversityAbstract Diabetes mellitus (DM) is a major global health concern associated with complications that significantly impair quality of life. Among these, the impact of DM on visual function and the underlying mechanisms, particularly the role of sleep quality, remain insufficiently understood. This cross-sectional study recruited 629 participants from Henan Provincial People’s Hospital to examine the relationships among DM, sleep quality, and visual function. Visual function was assessed using the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25), while sleep quality was evaluated with the Pittsburgh Sleep Quality Index (PSQI). Compared to non-diabetic controls, individuals with DM exhibited significantly poorer visual function and sleep quality. Path analysis further revealed that sleep quality played a significant mediating role in the relationship between DM and visual function, accounting for 42.2% of the total effect. Subgroup analyses indicated that female and elderly patients with DM were more susceptible to the influence of sleep disturbances on visual outcomes. These findings underscore the critical role of sleep quality in diabetes-related visual impairment and highlight the importance of incorporating routine sleep assessments and targeted interventions into diabetes management to help preserve visual function and improve overall quality of life in diabetic populations.https://doi.org/10.1038/s41598-025-06641-2Diabetes mellitusVisual functionSleep qualityMediating effectCross-Sectional study |
| spellingShingle | Yingrui Yang Xiaoting Pei Jiali Sun Mengting Xia Lina Tian Yanxia Kang Zhijie Li Mediating role of sleep quality in the relationship between diabetes mellitus and visual function: a cross-sectional study Scientific Reports Diabetes mellitus Visual function Sleep quality Mediating effect Cross-Sectional study |
| title | Mediating role of sleep quality in the relationship between diabetes mellitus and visual function: a cross-sectional study |
| title_full | Mediating role of sleep quality in the relationship between diabetes mellitus and visual function: a cross-sectional study |
| title_fullStr | Mediating role of sleep quality in the relationship between diabetes mellitus and visual function: a cross-sectional study |
| title_full_unstemmed | Mediating role of sleep quality in the relationship between diabetes mellitus and visual function: a cross-sectional study |
| title_short | Mediating role of sleep quality in the relationship between diabetes mellitus and visual function: a cross-sectional study |
| title_sort | mediating role of sleep quality in the relationship between diabetes mellitus and visual function a cross sectional study |
| topic | Diabetes mellitus Visual function Sleep quality Mediating effect Cross-Sectional study |
| url | https://doi.org/10.1038/s41598-025-06641-2 |
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