Novel temperature responsive polymer based sealant for embolization
A sealant has been developed that improves upon current catheter-based treatments in the following ways: 1) Efficient delivery system, 2) No in situ polymerization, 3) No harmful byproducts, and 4) Cost-effective formulation. During the development process, particular attention was given to material...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Science and Technology of Advanced Materials |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/14686996.2024.2409059 |
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| author | Ali E. Dabiri Ravin Narain Yi-Yang Peng Wenda Wang Max Itkins Ghassan S. Kassab |
| author_facet | Ali E. Dabiri Ravin Narain Yi-Yang Peng Wenda Wang Max Itkins Ghassan S. Kassab |
| author_sort | Ali E. Dabiri |
| collection | DOAJ |
| description | A sealant has been developed that improves upon current catheter-based treatments in the following ways: 1) Efficient delivery system, 2) No in situ polymerization, 3) No harmful byproducts, and 4) Cost-effective formulation. During the development process, particular attention was given to materials that were tunable, safe, and effective sealant agents. The thermo-responsive properties of poly(N-isopropylacrylamide) (PNIPAM) provides an ideal foundation to develop an optimized solution. Through a combination of model-based and material testing, a hydrogel was developed that balances conformational factors to achieve a customized transition temperature, radiopacity suitable for visualization, mechanical properties suitable for delivery via 3Fr catheter, sufficient cohesion once applied to resist migration under physiological pressures and an improved safety profile. Two applications, embolization of lymphatic leakage and exclusions of the left atrial appendage (LAA), to eliminate LAA dead space to reduce the risk of thromboembolic events, were considered. The material and benchtop results for this product demonstrate the suitability of this new material not only for these applications but also for other potential healthcare applications. |
| format | Article |
| id | doaj-art-98abc9fd103f489a81f230953c35d30c |
| institution | Kabale University |
| issn | 1468-6996 1878-5514 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Science and Technology of Advanced Materials |
| spelling | doaj-art-98abc9fd103f489a81f230953c35d30c2024-12-23T08:54:38ZengTaylor & Francis GroupScience and Technology of Advanced Materials1468-69961878-55142024-12-0125110.1080/14686996.2024.2409059Novel temperature responsive polymer based sealant for embolizationAli E. Dabiri0Ravin Narain1Yi-Yang Peng2Wenda Wang3Max Itkins4Ghassan S. Kassab53DTholdings, San Diego, CA, USADepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, CanadaDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, CanadaDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, CanadaHospital of the University of Pennsylvania, Philadelphia, PA, USACalifornia Medical Innovation Institute, San Diego, CA, USAA sealant has been developed that improves upon current catheter-based treatments in the following ways: 1) Efficient delivery system, 2) No in situ polymerization, 3) No harmful byproducts, and 4) Cost-effective formulation. During the development process, particular attention was given to materials that were tunable, safe, and effective sealant agents. The thermo-responsive properties of poly(N-isopropylacrylamide) (PNIPAM) provides an ideal foundation to develop an optimized solution. Through a combination of model-based and material testing, a hydrogel was developed that balances conformational factors to achieve a customized transition temperature, radiopacity suitable for visualization, mechanical properties suitable for delivery via 3Fr catheter, sufficient cohesion once applied to resist migration under physiological pressures and an improved safety profile. Two applications, embolization of lymphatic leakage and exclusions of the left atrial appendage (LAA), to eliminate LAA dead space to reduce the risk of thromboembolic events, were considered. The material and benchtop results for this product demonstrate the suitability of this new material not only for these applications but also for other potential healthcare applications.https://www.tandfonline.com/doi/10.1080/14686996.2024.2409059Glueatrial fibrillationinjectable hydrogelself-healing hydrogellymphatic leakage |
| spellingShingle | Ali E. Dabiri Ravin Narain Yi-Yang Peng Wenda Wang Max Itkins Ghassan S. Kassab Novel temperature responsive polymer based sealant for embolization Science and Technology of Advanced Materials Glue atrial fibrillation injectable hydrogel self-healing hydrogel lymphatic leakage |
| title | Novel temperature responsive polymer based sealant for embolization |
| title_full | Novel temperature responsive polymer based sealant for embolization |
| title_fullStr | Novel temperature responsive polymer based sealant for embolization |
| title_full_unstemmed | Novel temperature responsive polymer based sealant for embolization |
| title_short | Novel temperature responsive polymer based sealant for embolization |
| title_sort | novel temperature responsive polymer based sealant for embolization |
| topic | Glue atrial fibrillation injectable hydrogel self-healing hydrogel lymphatic leakage |
| url | https://www.tandfonline.com/doi/10.1080/14686996.2024.2409059 |
| work_keys_str_mv | AT aliedabiri noveltemperatureresponsivepolymerbasedsealantforembolization AT ravinnarain noveltemperatureresponsivepolymerbasedsealantforembolization AT yiyangpeng noveltemperatureresponsivepolymerbasedsealantforembolization AT wendawang noveltemperatureresponsivepolymerbasedsealantforembolization AT maxitkins noveltemperatureresponsivepolymerbasedsealantforembolization AT ghassanskassab noveltemperatureresponsivepolymerbasedsealantforembolization |