Characteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: a matched case-control from the Brazilian Covid-19 Registry
Abstract Background The Covid-19 pandemic caused a negative impact on other infectious diseases control, prevention, and treatment. Consequently, low and middle-income countries suffer from other endemic diseases, such as tuberculosis. This study was designed to compare Covid-19 manifestations and o...
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BMC
2024-12-01
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| Online Access: | https://doi.org/10.1186/s12879-024-10305-3 |
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| author | Rafael Lima Rodrigues de Carvalho Daniella Nunes Pereira Victor Schulthais Chagas Valéria Maria Augusto Felício Roberto Costa Guilherme Fagundes Nascimento Karen Brasil Ruschel Leila Beltrami Moreira Marcelo Carneiro Milton Henriques Guimarães Júnior Mônica Aparecida Costa Naiara Patrícia Fagundes Bonardi Neimy Ramos de Oliveira Rubia Laura Oliveira Aguiar Raíssa de Melo Costa Magda Carvalho Pires Milena Soriano Marcolino |
| author_facet | Rafael Lima Rodrigues de Carvalho Daniella Nunes Pereira Victor Schulthais Chagas Valéria Maria Augusto Felício Roberto Costa Guilherme Fagundes Nascimento Karen Brasil Ruschel Leila Beltrami Moreira Marcelo Carneiro Milton Henriques Guimarães Júnior Mônica Aparecida Costa Naiara Patrícia Fagundes Bonardi Neimy Ramos de Oliveira Rubia Laura Oliveira Aguiar Raíssa de Melo Costa Magda Carvalho Pires Milena Soriano Marcolino |
| author_sort | Rafael Lima Rodrigues de Carvalho |
| collection | DOAJ |
| description | Abstract Background The Covid-19 pandemic caused a negative impact on other infectious diseases control, prevention, and treatment. Consequently, low and middle-income countries suffer from other endemic diseases, such as tuberculosis. This study was designed to compare Covid-19 manifestations and outcomes between patients with previously treated tuberculosis and controls without this condition. Methods We performed a matched case-control study drawn from the Brazilian Covid-19 Registry data, including in-hospital patients aged 18 and over with laboratory-confirmed Covid-19 from March 1, 2020, to March 31, 2022. Cases were patients with a past history of tuberculosis. Controls were Covid-19 patients without a tuberculosis history. Patients were matched by hospital, sex, presence of HIV, and number of comorbidities, with a 1:4 ratio. Results Of 13,636 patients with laboratory-confirmed diagnoses of Covid-19 enrolled in this study, 80 had a history of tuberculosis. Statistical differences in history of chronic pulmonary obstructive disease (15% vs. 3.2%), psychiatric disease (10% vs. 3.5%,), chronic kidney disease (11.2% vs. 2.8%), and solid-organ transplantation; (5% vs. 0.9%, p < 0.05 for all) were higher in patients with a past history of tuberculosis. Prior use of inhalatory medications (5% vs. 0.6%,), oral corticoids (8.8% vs. 1.9%), immunosuppressants (8.8% vs. 1.9%,) and the use of illicit drugs were more common in the case group (6.2% vs. 0.3% p < 0.05for all). There were no significant differences in in-hospital mortality, mechanical ventilation, need for dialysis, and ICU admission. Conclusions Patients with a history of tuberculosis infection presented a higher frequency of use of illicit drugs, chronic pulmonary obstructive disease, psychiatric disease, chronic kidney disease, solid-organ transplantation, prior use of inhalatory medications, oral corticoids, and immunosuppressants. The outcomes were similar between cases and controls. |
| format | Article |
| id | doaj-art-988f1546f7014a5f83e2cd7fe8de0d78 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-988f1546f7014a5f83e2cd7fe8de0d782024-12-22T12:17:48ZengBMCBMC Infectious Diseases1471-23342024-12-012411810.1186/s12879-024-10305-3Characteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: a matched case-control from the Brazilian Covid-19 RegistryRafael Lima Rodrigues de Carvalho0Daniella Nunes Pereira1Victor Schulthais Chagas2Valéria Maria Augusto3Felício Roberto Costa4Guilherme Fagundes Nascimento5Karen Brasil Ruschel6Leila Beltrami Moreira7Marcelo Carneiro8Milton Henriques Guimarães Júnior9Mônica Aparecida Costa10Naiara Patrícia Fagundes Bonardi11Neimy Ramos de Oliveira12Rubia Laura Oliveira Aguiar13Raíssa de Melo Costa14Magda Carvalho Pires15Milena Soriano Marcolino16School of Nursing, Universidade Federal da BahiaMedical School, Universidade Federal de Minas GeraisTelehealth Center, Hospital das Clínicas da UFMG, Universidade Federal de Minas GeraisDepartment of Internal Medicine, Medical School, Universidade Federal de Minas GeraisHospital Metropolitano Odilon Behrens. R. Formiga, 50Hospital da UnimedInstitute for Health Technology Assessment (IATS/CNPq)Hospital de Clínicas de Porto Alegre. Rua Ramiro BarcelosHospital Santa CruzHospital Márcio CunhaHospital Risoleta Tolentino NevesHospital São João de DeusHospital Eduardo de MenezesHospital Metropolitano Doutor Célio de CastroTelehealth Center, Hospital das Clínicas da UFMG, Universidade Federal de Minas GeraisDepartment of Statistics, Universidade Federal de Minas GeraisInstitute for Health Technology Assessment (IATS/CNPq)Abstract Background The Covid-19 pandemic caused a negative impact on other infectious diseases control, prevention, and treatment. Consequently, low and middle-income countries suffer from other endemic diseases, such as tuberculosis. This study was designed to compare Covid-19 manifestations and outcomes between patients with previously treated tuberculosis and controls without this condition. Methods We performed a matched case-control study drawn from the Brazilian Covid-19 Registry data, including in-hospital patients aged 18 and over with laboratory-confirmed Covid-19 from March 1, 2020, to March 31, 2022. Cases were patients with a past history of tuberculosis. Controls were Covid-19 patients without a tuberculosis history. Patients were matched by hospital, sex, presence of HIV, and number of comorbidities, with a 1:4 ratio. Results Of 13,636 patients with laboratory-confirmed diagnoses of Covid-19 enrolled in this study, 80 had a history of tuberculosis. Statistical differences in history of chronic pulmonary obstructive disease (15% vs. 3.2%), psychiatric disease (10% vs. 3.5%,), chronic kidney disease (11.2% vs. 2.8%), and solid-organ transplantation; (5% vs. 0.9%, p < 0.05 for all) were higher in patients with a past history of tuberculosis. Prior use of inhalatory medications (5% vs. 0.6%,), oral corticoids (8.8% vs. 1.9%), immunosuppressants (8.8% vs. 1.9%,) and the use of illicit drugs were more common in the case group (6.2% vs. 0.3% p < 0.05for all). There were no significant differences in in-hospital mortality, mechanical ventilation, need for dialysis, and ICU admission. Conclusions Patients with a history of tuberculosis infection presented a higher frequency of use of illicit drugs, chronic pulmonary obstructive disease, psychiatric disease, chronic kidney disease, solid-organ transplantation, prior use of inhalatory medications, oral corticoids, and immunosuppressants. The outcomes were similar between cases and controls.https://doi.org/10.1186/s12879-024-10305-3Covid-19TuberculosisHospitalizationInfectious diseases |
| spellingShingle | Rafael Lima Rodrigues de Carvalho Daniella Nunes Pereira Victor Schulthais Chagas Valéria Maria Augusto Felício Roberto Costa Guilherme Fagundes Nascimento Karen Brasil Ruschel Leila Beltrami Moreira Marcelo Carneiro Milton Henriques Guimarães Júnior Mônica Aparecida Costa Naiara Patrícia Fagundes Bonardi Neimy Ramos de Oliveira Rubia Laura Oliveira Aguiar Raíssa de Melo Costa Magda Carvalho Pires Milena Soriano Marcolino Characteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: a matched case-control from the Brazilian Covid-19 Registry BMC Infectious Diseases Covid-19 Tuberculosis Hospitalization Infectious diseases |
| title | Characteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: a matched case-control from the Brazilian Covid-19 Registry |
| title_full | Characteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: a matched case-control from the Brazilian Covid-19 Registry |
| title_fullStr | Characteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: a matched case-control from the Brazilian Covid-19 Registry |
| title_full_unstemmed | Characteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: a matched case-control from the Brazilian Covid-19 Registry |
| title_short | Characteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: a matched case-control from the Brazilian Covid-19 Registry |
| title_sort | characteristics and outcomes of in hospital patients with covid 19 and history of tuberculosis a matched case control from the brazilian covid 19 registry |
| topic | Covid-19 Tuberculosis Hospitalization Infectious diseases |
| url | https://doi.org/10.1186/s12879-024-10305-3 |
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