Research progress of CD80 in the development of immunotherapy drugs
CD80 is a molecule that plays an important role in the immune system, especially during T-cell activation, and its ligands are mainly CD28, PD-L1, and CTLA-4. CD80 is expressed on the surface of tumor cells, and it can be used as a molecular target in the process of T-cell anti-tumor immune response...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1496992/full |
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| author | Lanying Li Lei Yang DePeng Jiang |
| author_facet | Lanying Li Lei Yang DePeng Jiang |
| author_sort | Lanying Li |
| collection | DOAJ |
| description | CD80 is a molecule that plays an important role in the immune system, especially during T-cell activation, and its ligands are mainly CD28, PD-L1, and CTLA-4. CD80 is expressed on the surface of tumor cells, and it can be used as a molecular target in the process of T-cell anti-tumor immune response. In autoimmune diseases, CD80 can also regulate autoimmune diseases by modulating immunity. This review mainly focus on the role of CD80 in the immune system, as well as the research progress on the application of CD80-related immunopharmaceuticals in the treatment of tumors and autoimmune diseases. |
| format | Article |
| id | doaj-art-98825bcc4fdb496f8b205f1355b922e0 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-98825bcc4fdb496f8b205f1355b922e02024-12-18T10:20:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-11-011510.3389/fimmu.2024.14969921496992Research progress of CD80 in the development of immunotherapy drugsLanying LiLei YangDePeng JiangCD80 is a molecule that plays an important role in the immune system, especially during T-cell activation, and its ligands are mainly CD28, PD-L1, and CTLA-4. CD80 is expressed on the surface of tumor cells, and it can be used as a molecular target in the process of T-cell anti-tumor immune response. In autoimmune diseases, CD80 can also regulate autoimmune diseases by modulating immunity. This review mainly focus on the role of CD80 in the immune system, as well as the research progress on the application of CD80-related immunopharmaceuticals in the treatment of tumors and autoimmune diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1496992/fullCD80immunotherapy drugsT cellstumorautoimmune diseases |
| spellingShingle | Lanying Li Lei Yang DePeng Jiang Research progress of CD80 in the development of immunotherapy drugs Frontiers in Immunology CD80 immunotherapy drugs T cells tumor autoimmune diseases |
| title | Research progress of CD80 in the development of immunotherapy drugs |
| title_full | Research progress of CD80 in the development of immunotherapy drugs |
| title_fullStr | Research progress of CD80 in the development of immunotherapy drugs |
| title_full_unstemmed | Research progress of CD80 in the development of immunotherapy drugs |
| title_short | Research progress of CD80 in the development of immunotherapy drugs |
| title_sort | research progress of cd80 in the development of immunotherapy drugs |
| topic | CD80 immunotherapy drugs T cells tumor autoimmune diseases |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1496992/full |
| work_keys_str_mv | AT lanyingli researchprogressofcd80inthedevelopmentofimmunotherapydrugs AT leiyang researchprogressofcd80inthedevelopmentofimmunotherapydrugs AT depengjiang researchprogressofcd80inthedevelopmentofimmunotherapydrugs |