Clinical Efficacy of Endocannabinoid-Mimetic Fatty Acid Amide as a Skin-Soothing Ingredient
Despite the potential benefits of cannabidiol as a skin-soothing ingredient, its regulatory status hampers its general use in cosmetic products in many countries. To develop an alternative to cannabidiol, fatty acid amide molecules mimicking the chemical structure of endocannabinoids were manufactur...
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| Format: | Article |
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MDPI AG
2024-12-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/11/6/225 |
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| author | Sungwoo Kim Yeonjae Kim Juyeon Jung Hyun-Jung Kim Sekyoo Jeong Heesung Shin Wuk-Sang Ryu Jung-Hoon Sohn Gaewon Nam |
| author_facet | Sungwoo Kim Yeonjae Kim Juyeon Jung Hyun-Jung Kim Sekyoo Jeong Heesung Shin Wuk-Sang Ryu Jung-Hoon Sohn Gaewon Nam |
| author_sort | Sungwoo Kim |
| collection | DOAJ |
| description | Despite the potential benefits of cannabidiol as a skin-soothing ingredient, its regulatory status hampers its general use in cosmetic products in many countries. To develop an alternative to cannabidiol, fatty acid amide molecules mimicking the chemical structure of endocannabinoids were manufactured using a lipase-catalyzed process. A mixture of fatty acid amides from sunflower oil and 1-amino propan-3-ol was synthesized using an immobilized lipase reaction, and the activation of cannabinoid receptor 1 (CB1R) was measured using a cAMP assay. The anti-inflammatory activity of the endocannabimimetic ingredients was evaluated in cultured human monocytes and ex vivo human skin explant models. A clinical study was conducted to address the skin hydration, skin barrier function, and skin redness, and the ratio of the interleukin-1-receptor antagonist (IL1-RA) to IL-1α in corneocytes, as a marker for skin sensitivity, were also measured. As a result, the activation of CB1R by endocannabimimetic ingredients was observed in cAMP assays, and a reduction in inflammatory responses by human monocytes induced by lipopolysaccharide treatment were also observed. External stress-induced inflammatory responses were reduced in ex vivo human skin explants. Improvements in skin hydration and barrier function were observed in a clinical study. A significant decrease in skin redness and the IL-1RA to IL-1α ratio was also observed. Endocannabimimetic ingredients, as alternatives to cannabidiol, can be used in skin-soothing cosmetics to increase skin hydration, improve skin barrier function, and reduce skin sensitivity. |
| format | Article |
| id | doaj-art-9859e32ddc3e4b4b9c30663485c8acd3 |
| institution | Kabale University |
| issn | 2079-9284 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj-art-9859e32ddc3e4b4b9c30663485c8acd32024-12-27T14:19:25ZengMDPI AGCosmetics2079-92842024-12-0111622510.3390/cosmetics11060225Clinical Efficacy of Endocannabinoid-Mimetic Fatty Acid Amide as a Skin-Soothing IngredientSungwoo Kim0Yeonjae Kim1Juyeon Jung2Hyun-Jung Kim3Sekyoo Jeong4Heesung Shin5Wuk-Sang Ryu6Jung-Hoon Sohn7Gaewon Nam8Department of Dermatology, Chungnam National University Sejong Hospital, Sejong 30099, Republic of KoreaResearch Team, Incospharm Corp., Daejeon 43000, Republic of KoreaResearch Team, Incospharm Corp., Daejeon 43000, Republic of KoreaDepartment of Dermatology, Chungnam National University Sejong Hospital, Sejong 30099, Republic of KoreaResearch Team, Incospharm Corp., Daejeon 43000, Republic of KoreaR&D Center, Cellapy Bio Inc., Daejeon 34141, Republic of KoreaR&D Center, Cellapy Bio Inc., Daejeon 34141, Republic of KoreaR&D Center, Cellapy Bio Inc., Daejeon 34141, Republic of KoreaDepartment of Bio-Cosmetic Science, Seowon University, Cheongju 28674, Republic of KoreaDespite the potential benefits of cannabidiol as a skin-soothing ingredient, its regulatory status hampers its general use in cosmetic products in many countries. To develop an alternative to cannabidiol, fatty acid amide molecules mimicking the chemical structure of endocannabinoids were manufactured using a lipase-catalyzed process. A mixture of fatty acid amides from sunflower oil and 1-amino propan-3-ol was synthesized using an immobilized lipase reaction, and the activation of cannabinoid receptor 1 (CB1R) was measured using a cAMP assay. The anti-inflammatory activity of the endocannabimimetic ingredients was evaluated in cultured human monocytes and ex vivo human skin explant models. A clinical study was conducted to address the skin hydration, skin barrier function, and skin redness, and the ratio of the interleukin-1-receptor antagonist (IL1-RA) to IL-1α in corneocytes, as a marker for skin sensitivity, were also measured. As a result, the activation of CB1R by endocannabimimetic ingredients was observed in cAMP assays, and a reduction in inflammatory responses by human monocytes induced by lipopolysaccharide treatment were also observed. External stress-induced inflammatory responses were reduced in ex vivo human skin explants. Improvements in skin hydration and barrier function were observed in a clinical study. A significant decrease in skin redness and the IL-1RA to IL-1α ratio was also observed. Endocannabimimetic ingredients, as alternatives to cannabidiol, can be used in skin-soothing cosmetics to increase skin hydration, improve skin barrier function, and reduce skin sensitivity.https://www.mdpi.com/2079-9284/11/6/225endocannabinoidsendocannabimimeticskin soothingfatty acid amidesclinical efficacy |
| spellingShingle | Sungwoo Kim Yeonjae Kim Juyeon Jung Hyun-Jung Kim Sekyoo Jeong Heesung Shin Wuk-Sang Ryu Jung-Hoon Sohn Gaewon Nam Clinical Efficacy of Endocannabinoid-Mimetic Fatty Acid Amide as a Skin-Soothing Ingredient Cosmetics endocannabinoids endocannabimimetic skin soothing fatty acid amides clinical efficacy |
| title | Clinical Efficacy of Endocannabinoid-Mimetic Fatty Acid Amide as a Skin-Soothing Ingredient |
| title_full | Clinical Efficacy of Endocannabinoid-Mimetic Fatty Acid Amide as a Skin-Soothing Ingredient |
| title_fullStr | Clinical Efficacy of Endocannabinoid-Mimetic Fatty Acid Amide as a Skin-Soothing Ingredient |
| title_full_unstemmed | Clinical Efficacy of Endocannabinoid-Mimetic Fatty Acid Amide as a Skin-Soothing Ingredient |
| title_short | Clinical Efficacy of Endocannabinoid-Mimetic Fatty Acid Amide as a Skin-Soothing Ingredient |
| title_sort | clinical efficacy of endocannabinoid mimetic fatty acid amide as a skin soothing ingredient |
| topic | endocannabinoids endocannabimimetic skin soothing fatty acid amides clinical efficacy |
| url | https://www.mdpi.com/2079-9284/11/6/225 |
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