Uvaol attenuates TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells by modulating expression and membrane localization of β-catenin

Uvaol attenuates TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells by modulating expression and membrane localization of β-catenin

The epithelial-mesenchymal transition (EMT) is a biological process in which epithelial cells change into mesenchymal cells with fibroblast-like characteristics. EMT plays a crucial role in the progression of fibrosis. Classical inducers associated with the maintenance of EMT, such as TGF-β1, have b...

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Bibliographic Details
Main Authors: Liliane Patrícia Gonçalves Tenório, Felipe Henrique da Cunha Xavier, Mônica Silveira Wagner, Kayo Moreira Bagri, Erick Gabriel Alves Ferreira, Romulo Galvani, Claudia Mermelstein, Adriana Cesar Bonomo, Wilson Savino, Emiliano Barreto
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
uvaol
TGF-β1
epithelial-mesenchymal transition
β-catenin
cell migration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1504556/full
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