N-Acetylneuraminic acid triggers endothelial pyroptosis and promotes atherosclerosis progression via GLS2-mediated glutaminolysis pathway

N-Acetylneuraminic acid triggers endothelial pyroptosis and promotes atherosclerosis progression via GLS2-mediated glutaminolysis pathway

Abstract Vascular endothelial injury initiates atherosclerosis (AS) progression. N-Acetylneuraminic acid (Neu5Ac) metabolic disorder was found to intensify endothelial mitochondrial damage. And GLS2-associated glutaminolysis disorder contributed to mitochondrial dysfunction. However, mechanisms unde...

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Main Authors: Zhaohong Liu, Peng Xiang, Shengmei Zeng, Ping Weng, Yilin Wen, Wanping Zhang, Hui Hu, Dezhang Zhao, Limei Ma, Chao Yu
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02233-7
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