Causes and countermeasures for the increased infection and COVID-19 mortality rates in patients with schizophrenia
Schizophrenia (SCZ) is a common psychiatric disorder that has a complex pathological mechanism. During the Coronavirus disease 2019 (COVID-19) epidemic, patients with SCZ had substantially higher rates of infection with SARS-CoV-2, the virus that causes COVID-19, as well as higher COVID-19 mortality...
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Elsevier
2024-12-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242124001027 |
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| author | Zhen-Ying Li Yu-Qian Li Jing-Ru Zhou Jie Wang Kun-Ze Liu Peng Wang Chun-Mei Gong Han Wang Yu-Jing Zhang Yu Cao Yue Gu Han-Bo Zhang Hui Lu Li-Fang Lu Ren-Jun Feng |
| author_facet | Zhen-Ying Li Yu-Qian Li Jing-Ru Zhou Jie Wang Kun-Ze Liu Peng Wang Chun-Mei Gong Han Wang Yu-Jing Zhang Yu Cao Yue Gu Han-Bo Zhang Hui Lu Li-Fang Lu Ren-Jun Feng |
| author_sort | Zhen-Ying Li |
| collection | DOAJ |
| description | Schizophrenia (SCZ) is a common psychiatric disorder that has a complex pathological mechanism. During the Coronavirus disease 2019 (COVID-19) epidemic, patients with SCZ had substantially higher rates of infection with SARS-CoV-2, the virus that causes COVID-19, as well as higher COVID-19 mortality relative to patients with other mental disorders. However, the reasons for these increased rates in patients with SCZ remain unknown. In this review, we hypothesize that certain molecular pathways exhibit abnormal function in both COVID-19 and SCZ, with a focus on those related to energy metabolism dysregulation, immune system disruption, and abnormalities of the central nervous system. We review that dysregulation of energy metabolism can result in disruptions to the immune system and abnormalities within the central nervous system (CNS). Furthermore, immune system disturbances may also contribute to CNS abnormalities in both SCZ and COVID-19. We also discuss macro-factors associated with the high infection and mortality rates of COVID-19 in patients with SCZ, including sociodemographic factors, reduced access to psychiatric healthcare, structural barriers to COVID-19 vaccination, and proposed approaches to mitigate these macro-factors. |
| format | Article |
| id | doaj-art-97fdd568e8254714b06a8fbda955b82c |
| institution | Kabale University |
| issn | 2667-2421 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj-art-97fdd568e8254714b06a8fbda955b82c2024-11-22T07:39:44ZengElsevierIBRO Neuroscience Reports2667-24212024-12-0117456462Causes and countermeasures for the increased infection and COVID-19 mortality rates in patients with schizophreniaZhen-Ying Li0Yu-Qian Li1Jing-Ru Zhou2Jie Wang3Kun-Ze Liu4Peng Wang5Chun-Mei Gong6Han Wang7Yu-Jing Zhang8Yu Cao9Yue Gu10Han-Bo Zhang11Hui Lu12Li-Fang Lu13Ren-Jun Feng14Key Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, ChinaThe First Clinical College & The Second Clinical College, Hainan Medical University, Haikou, ChinaThe First Clinical College & The Second Clinical College, Hainan Medical University, Haikou, ChinaHainan Women and Children's Medical Center, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, ChinaDepartment of Medical Physiology, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, ChinaThe First Clinical College & The Second Clinical College, Hainan Medical University, Haikou, ChinaThe First Clinical College & The Second Clinical College, Hainan Medical University, Haikou, ChinaKey Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, China; Department of Medical Physiology, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, China; Corresponding authors at: Key Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, China.Key Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, China; Department of Human Anatomy, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, China; Department of Biology, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, China; Corresponding authors at: Key Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, China.Schizophrenia (SCZ) is a common psychiatric disorder that has a complex pathological mechanism. During the Coronavirus disease 2019 (COVID-19) epidemic, patients with SCZ had substantially higher rates of infection with SARS-CoV-2, the virus that causes COVID-19, as well as higher COVID-19 mortality relative to patients with other mental disorders. However, the reasons for these increased rates in patients with SCZ remain unknown. In this review, we hypothesize that certain molecular pathways exhibit abnormal function in both COVID-19 and SCZ, with a focus on those related to energy metabolism dysregulation, immune system disruption, and abnormalities of the central nervous system. We review that dysregulation of energy metabolism can result in disruptions to the immune system and abnormalities within the central nervous system (CNS). Furthermore, immune system disturbances may also contribute to CNS abnormalities in both SCZ and COVID-19. We also discuss macro-factors associated with the high infection and mortality rates of COVID-19 in patients with SCZ, including sociodemographic factors, reduced access to psychiatric healthcare, structural barriers to COVID-19 vaccination, and proposed approaches to mitigate these macro-factors.http://www.sciencedirect.com/science/article/pii/S2667242124001027SchizophreniaCOVID-19Molecular mechanismMacro-factorsSolutions |
| spellingShingle | Zhen-Ying Li Yu-Qian Li Jing-Ru Zhou Jie Wang Kun-Ze Liu Peng Wang Chun-Mei Gong Han Wang Yu-Jing Zhang Yu Cao Yue Gu Han-Bo Zhang Hui Lu Li-Fang Lu Ren-Jun Feng Causes and countermeasures for the increased infection and COVID-19 mortality rates in patients with schizophrenia IBRO Neuroscience Reports Schizophrenia COVID-19 Molecular mechanism Macro-factors Solutions |
| title | Causes and countermeasures for the increased infection and COVID-19 mortality rates in patients with schizophrenia |
| title_full | Causes and countermeasures for the increased infection and COVID-19 mortality rates in patients with schizophrenia |
| title_fullStr | Causes and countermeasures for the increased infection and COVID-19 mortality rates in patients with schizophrenia |
| title_full_unstemmed | Causes and countermeasures for the increased infection and COVID-19 mortality rates in patients with schizophrenia |
| title_short | Causes and countermeasures for the increased infection and COVID-19 mortality rates in patients with schizophrenia |
| title_sort | causes and countermeasures for the increased infection and covid 19 mortality rates in patients with schizophrenia |
| topic | Schizophrenia COVID-19 Molecular mechanism Macro-factors Solutions |
| url | http://www.sciencedirect.com/science/article/pii/S2667242124001027 |
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