Ponatinib alleviates non-alcoholic steatohepatitis through TFEB-mediated autophagy

Ponatinib alleviates non-alcoholic steatohepatitis through TFEB-mediated autophagy

ObjectiveNon-alcoholic steatohepatitis (NASH) is a progressive liver disease with lipid accumulation, inflammation, and liver fibrosis. Ponatinib, a third-generation tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia, was found to improve metabolic disorders in mice. However, t...

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Bibliographic Details
Main Authors:	Zhuomiao Lin, Meiqing Yang, Xihui Yu, Guozhu Tan, Jiahong Zhong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Pharmacology
Subjects:	ponatinib NASH autophagy TFEB methionine and choline deficient diet
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1505768/full
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