Inhibition of autophagy enhances the antitumor efficacy of T/CAR T cell against neuroblastoma

Inhibition of autophagy enhances the antitumor efficacy of T/CAR T cell against neuroblastoma

Abstract Neuroblastoma (NB) is the most common extracranial solid tumor in children characterized by poor immune infiltration and resistance to adaptive immunity, contributing to its limited response to immunotherapy. A key mechanism underlying immune evasion in cancer is autophagy, a cellular proce...

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Main Authors: Francesca De Mitri, Manuela Giansanti, Ombretta Melaiu, Dorothee Haas, Stefan Ebert, Nicola Tumino, Elisabetta Vulpis, Francesca Gatto, Beatrice Martuscelli, Manuela Antonioli, Elisabetta Sangiuliano, Simona Caruso, Marco Scarsella, Cristiano De Stefanis, Veronica Marabitti, Silvia Campello, Doriana Fruci, Paola Vacca, Ignazio Caruana, Francesca Nazio
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Neuroblastoma
Immune cells
GD2.CAR T
Chloroquine
ULK1 inhibitor
Online Access:https://doi.org/10.1186/s13046-025-03453-0
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