A nomogram clinical model for predicting preoperative lower limb venous thrombosis in knee ligament injuries: a retrospective study
PurposeTo identify independent risk factors for preoperative lower limb venous thrombosis (LLVT) in knee ligament injuries and to develop a diagnostic prediction model based on these factors.MethodsPatients with knee ligament injuries who presented to our hospital between July 2021 and December 2023...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1486625/full |
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| author | Jincai Duan Jincai Duan Tianjie Xiao Tianyou Xing Tianyou Xing Wei Qin Wei Qin Zhihui Wang Zhihui Wang Haoduan Dou Haoduan Dou Di Wu Yuanliang Du Yuanliang Du |
| author_facet | Jincai Duan Jincai Duan Tianjie Xiao Tianyou Xing Tianyou Xing Wei Qin Wei Qin Zhihui Wang Zhihui Wang Haoduan Dou Haoduan Dou Di Wu Yuanliang Du Yuanliang Du |
| author_sort | Jincai Duan |
| collection | DOAJ |
| description | PurposeTo identify independent risk factors for preoperative lower limb venous thrombosis (LLVT) in knee ligament injuries and to develop a diagnostic prediction model based on these factors.MethodsPatients with knee ligament injuries who presented to our hospital between July 2021 and December 2023 were included in this study. Logistic regression analysis was utilized to determine independent risk factors for preoperative LLVT in knee ligament injuries and to construct a diagnostic prediction model. The diagnostic performance of the model was evaluated using receiver operating characteristic curves (ROC) and calibration curves.ResultsCompared with the None-LLVT group, the LLVT group showed statistically significant differences in age, gender, damaged ligament site, injury-examination time, low density lipoprotein (LDL), glucose (G), D-dimer, and fibrinogen degradation products (FDP) (P < 0.05). Multivariate logistic regression analysis showed that gender (P = 0.006, 95% CI [1.647-19.450]), damaged ligament site (P = 0.016, 95% CI [1.385-23.060]), and D-dimer > 0.55 mg/L (P < 0.001, 95% CI [3.029-37.845]) were independent risk factors for preoperative LLVT in patients with knee ligament invasion. The ROC showed good diagnostic efficacy, with an area under the curve (AUC) of 0.888, and the calibration curves showed good agreement (mean absolute error = 0.013).ConclusionGender, damaged ligament site, and D-dimer level can be used as independent risk factors for the preoperative prediction of LLVT, and the nomogram model proposed in this study can better assist clinicians in making clinical decisions. |
| format | Article |
| id | doaj-art-97dbe4f11f1443509ab80de272a743a3 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-97dbe4f11f1443509ab80de272a743a32025-08-20T03:44:27ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-03-011210.3389/fmed.2025.14866251486625A nomogram clinical model for predicting preoperative lower limb venous thrombosis in knee ligament injuries: a retrospective studyJincai Duan0Jincai Duan1Tianjie Xiao2Tianyou Xing3Tianyou Xing4Wei Qin5Wei Qin6Zhihui Wang7Zhihui Wang8Haoduan Dou9Haoduan Dou10Di Wu11Yuanliang Du12Yuanliang Du13Department of Joint Surgery, Affiliated Hospital of Chengde Medical College, Hebei, ChinaGraduate School of Chengde Medical College, Hebei, ChinaDepartment of Traditional Chinese Medicine, Affiliated Hospital of Chengde Medical College, Hebei, ChinaDepartment of Joint Surgery, Affiliated Hospital of Chengde Medical College, Hebei, ChinaGraduate School of Chengde Medical College, Hebei, ChinaDepartment of Joint Surgery, Affiliated Hospital of Chengde Medical College, Hebei, ChinaGraduate School of Chengde Medical College, Hebei, ChinaDepartment of Joint Surgery, Affiliated Hospital of Chengde Medical College, Hebei, ChinaGraduate School of Chengde Medical College, Hebei, ChinaGraduate School of Chengde Medical College, Hebei, ChinaDepartment of Minimally Invasive Spine Surgery, Affiliated Hospital of Chengde Medical College, Hebei, ChinaDepartment of Joint Surgery, Affiliated Hospital of Chengde Medical College, Hebei, ChinaDepartment of Joint Surgery, Affiliated Hospital of Chengde Medical College, Hebei, ChinaGraduate School of Chengde Medical College, Hebei, ChinaPurposeTo identify independent risk factors for preoperative lower limb venous thrombosis (LLVT) in knee ligament injuries and to develop a diagnostic prediction model based on these factors.MethodsPatients with knee ligament injuries who presented to our hospital between July 2021 and December 2023 were included in this study. Logistic regression analysis was utilized to determine independent risk factors for preoperative LLVT in knee ligament injuries and to construct a diagnostic prediction model. The diagnostic performance of the model was evaluated using receiver operating characteristic curves (ROC) and calibration curves.ResultsCompared with the None-LLVT group, the LLVT group showed statistically significant differences in age, gender, damaged ligament site, injury-examination time, low density lipoprotein (LDL), glucose (G), D-dimer, and fibrinogen degradation products (FDP) (P < 0.05). Multivariate logistic regression analysis showed that gender (P = 0.006, 95% CI [1.647-19.450]), damaged ligament site (P = 0.016, 95% CI [1.385-23.060]), and D-dimer > 0.55 mg/L (P < 0.001, 95% CI [3.029-37.845]) were independent risk factors for preoperative LLVT in patients with knee ligament invasion. The ROC showed good diagnostic efficacy, with an area under the curve (AUC) of 0.888, and the calibration curves showed good agreement (mean absolute error = 0.013).ConclusionGender, damaged ligament site, and D-dimer level can be used as independent risk factors for the preoperative prediction of LLVT, and the nomogram model proposed in this study can better assist clinicians in making clinical decisions.https://www.frontiersin.org/articles/10.3389/fmed.2025.1486625/fullknee ligament injurieslower limb venous thrombosisnomogramdeep vein thrombosispredictive model |
| spellingShingle | Jincai Duan Jincai Duan Tianjie Xiao Tianyou Xing Tianyou Xing Wei Qin Wei Qin Zhihui Wang Zhihui Wang Haoduan Dou Haoduan Dou Di Wu Yuanliang Du Yuanliang Du A nomogram clinical model for predicting preoperative lower limb venous thrombosis in knee ligament injuries: a retrospective study Frontiers in Medicine knee ligament injuries lower limb venous thrombosis nomogram deep vein thrombosis predictive model |
| title | A nomogram clinical model for predicting preoperative lower limb venous thrombosis in knee ligament injuries: a retrospective study |
| title_full | A nomogram clinical model for predicting preoperative lower limb venous thrombosis in knee ligament injuries: a retrospective study |
| title_fullStr | A nomogram clinical model for predicting preoperative lower limb venous thrombosis in knee ligament injuries: a retrospective study |
| title_full_unstemmed | A nomogram clinical model for predicting preoperative lower limb venous thrombosis in knee ligament injuries: a retrospective study |
| title_short | A nomogram clinical model for predicting preoperative lower limb venous thrombosis in knee ligament injuries: a retrospective study |
| title_sort | nomogram clinical model for predicting preoperative lower limb venous thrombosis in knee ligament injuries a retrospective study |
| topic | knee ligament injuries lower limb venous thrombosis nomogram deep vein thrombosis predictive model |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1486625/full |
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