JAKi for Dermatomyositis
Dermatomyositis (DM) is a systemic autoimmune rheumatic disease which can affect multi-organs, such as skin, muscle and lung. Five myositis-specific autoantibodies, i.e., TIF1r, MDA5, NXP2, Mi2 and SAE, are sero-markers of diagnostic value. The treatments for DM included glucocorticoids, csDMARDs, I...
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2024-01-01
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| Series: | Journal of Clinical Rheumatology and Immunology |
| Online Access: | https://www.worldscientific.com/doi/10.1142/S266134172474016X |
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| _version_ | 1846169815214981120 |
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| author | Shuang Ye |
| author_facet | Shuang Ye |
| author_sort | Shuang Ye |
| collection | DOAJ |
| description | Dermatomyositis (DM) is a systemic autoimmune rheumatic disease which can affect multi-organs, such as skin, muscle and lung. Five myositis-specific autoantibodies, i.e., TIF1r, MDA5, NXP2, Mi2 and SAE, are sero-markers of diagnostic value. The treatments for DM included glucocorticoids, csDMARDs, IVIg and biologics, e.g., rituximab. Type I IFN pathway is considered to be crucial in the pathogenesis of DM and the evidence of JAK inhibitors as treatment option in DM is accumulating. Herein, four clinical scenarios of DM, i.e., MDA5+DM-ILD, TIF1r+ cancer-associated DM, NXP2+ adult DM with GI involvement, and MSA negative DM, are presented to reveal the trials and tribulations to tackle this very difficult disease. |
| format | Article |
| id | doaj-art-97c9ea0da41d44fd87ba14648fd2a75f |
| institution | Kabale University |
| issn | 2661-3417 2661-3425 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Clinical Rheumatology and Immunology |
| spelling | doaj-art-97c9ea0da41d44fd87ba14648fd2a75f2024-11-12T08:27:23ZengWorld Scientific PublishingJournal of Clinical Rheumatology and Immunology2661-34172661-34252024-01-0124supp01161610.1142/S266134172474016XJAKi for DermatomyositisShuang Ye0ChinaDermatomyositis (DM) is a systemic autoimmune rheumatic disease which can affect multi-organs, such as skin, muscle and lung. Five myositis-specific autoantibodies, i.e., TIF1r, MDA5, NXP2, Mi2 and SAE, are sero-markers of diagnostic value. The treatments for DM included glucocorticoids, csDMARDs, IVIg and biologics, e.g., rituximab. Type I IFN pathway is considered to be crucial in the pathogenesis of DM and the evidence of JAK inhibitors as treatment option in DM is accumulating. Herein, four clinical scenarios of DM, i.e., MDA5+DM-ILD, TIF1r+ cancer-associated DM, NXP2+ adult DM with GI involvement, and MSA negative DM, are presented to reveal the trials and tribulations to tackle this very difficult disease.https://www.worldscientific.com/doi/10.1142/S266134172474016X |
| spellingShingle | Shuang Ye JAKi for Dermatomyositis Journal of Clinical Rheumatology and Immunology |
| title | JAKi for Dermatomyositis |
| title_full | JAKi for Dermatomyositis |
| title_fullStr | JAKi for Dermatomyositis |
| title_full_unstemmed | JAKi for Dermatomyositis |
| title_short | JAKi for Dermatomyositis |
| title_sort | jaki for dermatomyositis |
| url | https://www.worldscientific.com/doi/10.1142/S266134172474016X |
| work_keys_str_mv | AT shuangye jakifordermatomyositis |