Advances in adhesion-related pathogenesis in Mycoplasma pneumoniae infection
Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia (CAP) and upper respiratory tract infections, particularly in children and immunocompromised individuals. The growing global prevalence of macrolide-resistant M. pneumoniae (MRMP) further emphasizes the urgent need to elucidate...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1613760/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849303646289788928 |
|---|---|
| author | Bingyue Sun Yaozheng Ling Junhui Li Li Ma Zige Jie Hongbing Luo Yang Li Guo Yin Mingwei Wang Fanzheng Meng Fanzheng Meng Man Gao Man Gao |
| author_facet | Bingyue Sun Yaozheng Ling Junhui Li Li Ma Zige Jie Hongbing Luo Yang Li Guo Yin Mingwei Wang Fanzheng Meng Fanzheng Meng Man Gao Man Gao |
| author_sort | Bingyue Sun |
| collection | DOAJ |
| description | Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia (CAP) and upper respiratory tract infections, particularly in children and immunocompromised individuals. The growing global prevalence of macrolide-resistant M. pneumoniae (MRMP) further emphasizes the urgent need to elucidate its pathogenic mechanisms. Among these, adhesion plays a central role, serving as a prerequisite for colonization and disease progression, and thus warrants detailed investigation. The terminal organelle of M. pneumoniae mediates both adhesion and gliding motility, facilitating colonization, tissue invasion, and potential systemic spread. In the lung, adhesion triggers cytotoxic effects through the release of hydrogen peroxide (H2O2) and CARDS toxin (CARDS TX), promotes excessive inflammatory responses, and enables immune evasion via antigenic variation. Extrapulmonary manifestations may also arise either from direct bacterial dissemination or autoimmune responses induced by molecular mimicry between bacterial and host antigens. In addition, recent advances suggest that therapies and vaccines directed at the adhesion mechanism of M. pneumoniae may offer promising strategies for combating MRMP infections. Although progress has been made, the adhesion-related pathogenesis of M. pneumoniae, as well as the prospects for therapies and vaccines targeting this mechanism, remains incompletely defined. This review synthesizes current insights into adhesion-mediated mechanisms and highlights emerging therapeutic strategies targeting adhesion, aiming to support more effective treatment and prevention of M. pneumoniae infection. |
| format | Article |
| id | doaj-art-97c9e613ca2f4740a3797087d5d1a56c |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-97c9e613ca2f4740a3797087d5d1a56c2025-08-20T03:55:59ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-07-011610.3389/fmicb.2025.16137601613760Advances in adhesion-related pathogenesis in Mycoplasma pneumoniae infectionBingyue Sun0Yaozheng Ling1Junhui Li2Li Ma3Zige Jie4Hongbing Luo5Yang Li6Guo Yin7Mingwei Wang8Fanzheng Meng9Fanzheng Meng10Man Gao11Man Gao12Department of Pediatric Respiration, Children’s Medical Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Pediatric Respiration, Children’s Medical Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Pediatric Respiration, Children’s Medical Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Pediatric Respiration, Children’s Medical Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Developmental and Behavioral Pediatrics, The First Hospital of Jilin University, Changchun, ChinaDepartment of Pediatric Respiration, Children’s Medical Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Pediatric Respiration, Children’s Medical Center, The First Hospital of Jilin University, Changchun, ChinaThe First Hospital of Jilin University, Changchun, ChinaNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, ChinaDepartment of Pediatric Respiration, Children’s Medical Center, The First Hospital of Jilin University, Changchun, ChinaCenter for Pathogen Biology and Infectious Diseases, The First Hospital of Jilin University, Changchun, ChinaDepartment of Pediatric Respiration, Children’s Medical Center, The First Hospital of Jilin University, Changchun, ChinaCenter for Pathogen Biology and Infectious Diseases, The First Hospital of Jilin University, Changchun, ChinaMycoplasma pneumoniae is a leading cause of community-acquired pneumonia (CAP) and upper respiratory tract infections, particularly in children and immunocompromised individuals. The growing global prevalence of macrolide-resistant M. pneumoniae (MRMP) further emphasizes the urgent need to elucidate its pathogenic mechanisms. Among these, adhesion plays a central role, serving as a prerequisite for colonization and disease progression, and thus warrants detailed investigation. The terminal organelle of M. pneumoniae mediates both adhesion and gliding motility, facilitating colonization, tissue invasion, and potential systemic spread. In the lung, adhesion triggers cytotoxic effects through the release of hydrogen peroxide (H2O2) and CARDS toxin (CARDS TX), promotes excessive inflammatory responses, and enables immune evasion via antigenic variation. Extrapulmonary manifestations may also arise either from direct bacterial dissemination or autoimmune responses induced by molecular mimicry between bacterial and host antigens. In addition, recent advances suggest that therapies and vaccines directed at the adhesion mechanism of M. pneumoniae may offer promising strategies for combating MRMP infections. Although progress has been made, the adhesion-related pathogenesis of M. pneumoniae, as well as the prospects for therapies and vaccines targeting this mechanism, remains incompletely defined. This review synthesizes current insights into adhesion-mediated mechanisms and highlights emerging therapeutic strategies targeting adhesion, aiming to support more effective treatment and prevention of M. pneumoniae infection.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1613760/fullM. pneumoniaterminal organelleadhesiontreatmentvaccines |
| spellingShingle | Bingyue Sun Yaozheng Ling Junhui Li Li Ma Zige Jie Hongbing Luo Yang Li Guo Yin Mingwei Wang Fanzheng Meng Fanzheng Meng Man Gao Man Gao Advances in adhesion-related pathogenesis in Mycoplasma pneumoniae infection Frontiers in Microbiology M. pneumonia terminal organelle adhesion treatment vaccines |
| title | Advances in adhesion-related pathogenesis in Mycoplasma pneumoniae infection |
| title_full | Advances in adhesion-related pathogenesis in Mycoplasma pneumoniae infection |
| title_fullStr | Advances in adhesion-related pathogenesis in Mycoplasma pneumoniae infection |
| title_full_unstemmed | Advances in adhesion-related pathogenesis in Mycoplasma pneumoniae infection |
| title_short | Advances in adhesion-related pathogenesis in Mycoplasma pneumoniae infection |
| title_sort | advances in adhesion related pathogenesis in mycoplasma pneumoniae infection |
| topic | M. pneumonia terminal organelle adhesion treatment vaccines |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1613760/full |
| work_keys_str_mv | AT bingyuesun advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection AT yaozhengling advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection AT junhuili advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection AT lima advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection AT zigejie advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection AT hongbingluo advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection AT yangli advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection AT guoyin advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection AT mingweiwang advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection AT fanzhengmeng advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection AT fanzhengmeng advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection AT mangao advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection AT mangao advancesinadhesionrelatedpathogenesisinmycoplasmapneumoniaeinfection |