Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to Treatment
Inflammatory bowel disease (IBD) is a chronic condition that affects about 7 million people worldwide, and new therapies are needed. Understanding the complex roles that bile acids (BAs) play in IBD may lead to the development of novel IBD treatments independent of direct immunosuppression. This rev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/12/2910 |
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| _version_ | 1846105648081666048 |
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| author | Samantha H. Bai Arun Chandnani Siyan Cao |
| author_facet | Samantha H. Bai Arun Chandnani Siyan Cao |
| author_sort | Samantha H. Bai |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic condition that affects about 7 million people worldwide, and new therapies are needed. Understanding the complex roles that bile acids (BAs) play in IBD may lead to the development of novel IBD treatments independent of direct immunosuppression. This review discusses the latest discoveries in the roles BAs play in IBD pathogenesis and explores how these discoveries offer promising new therapeutic targets to treat IBD and improve patient outcomes. Several therapies discussed include specific BA receptor (BAR) agonists, dietary therapies, supplements, probiotics, and mesenchymal stem cell therapies that have all been shown to decrease IBD disease activity. |
| format | Article |
| id | doaj-art-97c703382e664b7bba8d2269a1a5897d |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-97c703382e664b7bba8d2269a1a5897d2024-12-27T14:13:14ZengMDPI AGBiomedicines2227-90592024-12-011212291010.3390/biomedicines12122910Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to TreatmentSamantha H. Bai0Arun Chandnani1Siyan Cao2Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USAInflammatory bowel disease (IBD) is a chronic condition that affects about 7 million people worldwide, and new therapies are needed. Understanding the complex roles that bile acids (BAs) play in IBD may lead to the development of novel IBD treatments independent of direct immunosuppression. This review discusses the latest discoveries in the roles BAs play in IBD pathogenesis and explores how these discoveries offer promising new therapeutic targets to treat IBD and improve patient outcomes. Several therapies discussed include specific BA receptor (BAR) agonists, dietary therapies, supplements, probiotics, and mesenchymal stem cell therapies that have all been shown to decrease IBD disease activity.https://www.mdpi.com/2227-9059/12/12/2910bile acidsinflammatory bowel diseaseulcerative colitisCrohn’s diseasepathogenesisnew therapies |
| spellingShingle | Samantha H. Bai Arun Chandnani Siyan Cao Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to Treatment Biomedicines bile acids inflammatory bowel disease ulcerative colitis Crohn’s disease pathogenesis new therapies |
| title | Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to Treatment |
| title_full | Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to Treatment |
| title_fullStr | Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to Treatment |
| title_full_unstemmed | Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to Treatment |
| title_short | Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to Treatment |
| title_sort | bile acids in inflammatory bowel disease from pathophysiology to treatment |
| topic | bile acids inflammatory bowel disease ulcerative colitis Crohn’s disease pathogenesis new therapies |
| url | https://www.mdpi.com/2227-9059/12/12/2910 |
| work_keys_str_mv | AT samanthahbai bileacidsininflammatoryboweldiseasefrompathophysiologytotreatment AT arunchandnani bileacidsininflammatoryboweldiseasefrompathophysiologytotreatment AT siyancao bileacidsininflammatoryboweldiseasefrompathophysiologytotreatment |