TREM1—Microglia crosstalk: Neurocognitive disorders
Neurocognitive Disorders (NCDs) primarily affect cognitive functions, including learning, memory, perception, and problem-solving. They predominantly arise as pathological sequelae of central nervous system (CNS) disorders. Emerging evidence suggests that microglial inflammatory activation within th...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S036192302400296X |
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| author | Huashan Li Wanqiu Yu Xue Zheng Zhaoqiong Zhu |
| author_facet | Huashan Li Wanqiu Yu Xue Zheng Zhaoqiong Zhu |
| author_sort | Huashan Li |
| collection | DOAJ |
| description | Neurocognitive Disorders (NCDs) primarily affect cognitive functions, including learning, memory, perception, and problem-solving. They predominantly arise as pathological sequelae of central nervous system (CNS) disorders. Emerging evidence suggests that microglial inflammatory activation within the hippocampus underlies the pathogenesis of cognitive impairment. Triggering receptor expressed on myeloid cells 1 (TREM1), a pattern-recognition receptor on microglia, becomes upregulated in response to injury and synergistically amplifies inflammatory responses mediated by other pattern-recognition receptors, leading to uncontrolled inflammation. While TREM1 is lowly expressed in the resting state, its upregulation upon exposure to injurious inflammatory stimuli promotes microglial activation and contributes to the development of NCDs. Consequently, TREM1 may serve as a critical receptor in microglia-mediated inflammation. This article reviews the current understanding of TREM1 and its role in NCDs pathogenesis. |
| format | Article |
| id | doaj-art-97b9dc054d4b44d290fc16758aad290d |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-97b9dc054d4b44d290fc16758aad290d2025-01-10T04:37:01ZengElsevierBrain Research Bulletin1873-27472025-01-01220111162TREM1—Microglia crosstalk: Neurocognitive disordersHuashan Li0Wanqiu Yu1Xue Zheng2Zhaoqiong Zhu3Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China; Department of Anesthesiology, Zunyi Maternal And Child Health Care Hospital, Zunyi 563000, ChinaDepartment of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, ChinaDepartment of Anesthesiology, Zunyi Maternal And Child Health Care Hospital, Zunyi 563000, ChinaEarly Clinical Research Ward, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China; Corresponding author.Neurocognitive Disorders (NCDs) primarily affect cognitive functions, including learning, memory, perception, and problem-solving. They predominantly arise as pathological sequelae of central nervous system (CNS) disorders. Emerging evidence suggests that microglial inflammatory activation within the hippocampus underlies the pathogenesis of cognitive impairment. Triggering receptor expressed on myeloid cells 1 (TREM1), a pattern-recognition receptor on microglia, becomes upregulated in response to injury and synergistically amplifies inflammatory responses mediated by other pattern-recognition receptors, leading to uncontrolled inflammation. While TREM1 is lowly expressed in the resting state, its upregulation upon exposure to injurious inflammatory stimuli promotes microglial activation and contributes to the development of NCDs. Consequently, TREM1 may serve as a critical receptor in microglia-mediated inflammation. This article reviews the current understanding of TREM1 and its role in NCDs pathogenesis.http://www.sciencedirect.com/science/article/pii/S036192302400296XTREM1MicrogliaNeuroinflammationNeurocognitive disordersCentral system diseases |
| spellingShingle | Huashan Li Wanqiu Yu Xue Zheng Zhaoqiong Zhu TREM1—Microglia crosstalk: Neurocognitive disorders Brain Research Bulletin TREM1 Microglia Neuroinflammation Neurocognitive disorders Central system diseases |
| title | TREM1—Microglia crosstalk: Neurocognitive disorders |
| title_full | TREM1—Microglia crosstalk: Neurocognitive disorders |
| title_fullStr | TREM1—Microglia crosstalk: Neurocognitive disorders |
| title_full_unstemmed | TREM1—Microglia crosstalk: Neurocognitive disorders |
| title_short | TREM1—Microglia crosstalk: Neurocognitive disorders |
| title_sort | trem1 microglia crosstalk neurocognitive disorders |
| topic | TREM1 Microglia Neuroinflammation Neurocognitive disorders Central system diseases |
| url | http://www.sciencedirect.com/science/article/pii/S036192302400296X |
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