Treatment for neovascular age-related macular degeneration: reasonable expectations of physicians and patients
<p> <b>A.B. Durasov</b> </p> <p> <b>Ophthalmology Clinic "Octopus" ("Tochka zreniya" Ltd), Samara, Russian Federation</b> </p> <p> <i>Neovascular age-related macular degeneration (nAMD) is a progressive chronic multif...
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Prime-Media
2021-09-01
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| Series: | РМЖ "Клиническая офтальмология" |
| Online Access: | http://clinopht.com/upload/iblock/fb9/fb9619ee072c2e60e9c880a2d52da754.pdf |
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| author | A.B. Durasov |
| author_facet | A.B. Durasov |
| author_sort | A.B. Durasov |
| collection | DOAJ |
| description | <p>
<b>A.B. Durasov</b>
</p>
<p>
<b>Ophthalmology Clinic "Octopus" ("Tochka zreniya" Ltd), Samara, Russian Federation</b>
</p>
<p>
<i>Neovascular age-related macular degeneration (nAMD) is a progressive chronic multifactorial disease requiring long-term, lifelong anti-VEGF therapy. Treatment outcomes are not always in line with the results of randomized clinical trials and do not meet the expectations for therapy whose success is assessed differently by patients and physicians. Good functional and anatomical results are expected from antivasoproliferative therapy under certain conditions, e.g., accurate evaluation of some patient characteristics (baseline visual acuity, type of choroidal neovascularization, comorbidities, status of retinal fluid and its differentiation), timely (as early as possible) treatment initiation after verifying diagnosis, and strict adherence to a proactive personalized "Treat-and-Extend" (T&E) regimen that implies a required number of injections with individual intervals. Poor adherence to treatment (non-compliance or nonpersistence of anti-VEGF therapy) significantly affects treatment outcomes in real-world clinical practice. This paper reviews criteria which predict the response to antivasoproliferative therapy and improving treatment adherence. The authors describe four fundamental principles to be met by an ideal regimen of anti-VEGF therapy for nAMD.</i>
</p>
<p>
<i><b>Keywords</b>: neovascular age-related macular degeneration, nAMD, "Treat-and-Extend", T&E, adherence, nonpersistence, anti-VEGF.</i>
</p>
<p>
<i><b>For citation:</b> Durasov A.B. Treatment for neovascular age-related macular degeneration: reasonable expectations of physicians and patients. Russian Journal of Clinical Ophthalmology. 2021;21(3):169–174</i><i> (in Russ.)</i><i>. DOI: 10.32364/2311-7729-2021-21-3-169-174.</i>
</p> |
| format | Article |
| id | doaj-art-97a801d9374b4542bbda2a31b1ab6952 |
| institution | Kabale University |
| issn | 2311-7729 2619-1571 |
| language | Russian |
| publishDate | 2021-09-01 |
| publisher | Prime-Media |
| record_format | Article |
| series | РМЖ "Клиническая офтальмология" |
| spelling | doaj-art-97a801d9374b4542bbda2a31b1ab69522025-01-16T09:39:38ZrusPrime-MediaРМЖ "Клиническая офтальмология"2311-77292619-15712021-09-0121331335Treatment for neovascular age-related macular degeneration: reasonable expectations of physicians and patientsA.B. Durasov0Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<p> <b>A.B. Durasov</b> </p> <p> <b>Ophthalmology Clinic "Octopus" ("Tochka zreniya" Ltd), Samara, Russian Federation</b> </p> <p> <i>Neovascular age-related macular degeneration (nAMD) is a progressive chronic multifactorial disease requiring long-term, lifelong anti-VEGF therapy. Treatment outcomes are not always in line with the results of randomized clinical trials and do not meet the expectations for therapy whose success is assessed differently by patients and physicians. Good functional and anatomical results are expected from antivasoproliferative therapy under certain conditions, e.g., accurate evaluation of some patient characteristics (baseline visual acuity, type of choroidal neovascularization, comorbidities, status of retinal fluid and its differentiation), timely (as early as possible) treatment initiation after verifying diagnosis, and strict adherence to a proactive personalized "Treat-and-Extend" (T&E) regimen that implies a required number of injections with individual intervals. Poor adherence to treatment (non-compliance or nonpersistence of anti-VEGF therapy) significantly affects treatment outcomes in real-world clinical practice. This paper reviews criteria which predict the response to antivasoproliferative therapy and improving treatment adherence. The authors describe four fundamental principles to be met by an ideal regimen of anti-VEGF therapy for nAMD.</i> </p> <p> <i><b>Keywords</b>: neovascular age-related macular degeneration, nAMD, "Treat-and-Extend", T&E, adherence, nonpersistence, anti-VEGF.</i> </p> <p> <i><b>For citation:</b> Durasov A.B. Treatment for neovascular age-related macular degeneration: reasonable expectations of physicians and patients. Russian Journal of Clinical Ophthalmology. 2021;21(3):169–174</i><i> (in Russ.)</i><i>. DOI: 10.32364/2311-7729-2021-21-3-169-174.</i> </p>http://clinopht.com/upload/iblock/fb9/fb9619ee072c2e60e9c880a2d52da754.pdf |
| spellingShingle | A.B. Durasov Treatment for neovascular age-related macular degeneration: reasonable expectations of physicians and patients РМЖ "Клиническая офтальмология" |
| title | Treatment for neovascular age-related macular degeneration: reasonable expectations of physicians and patients |
| title_full | Treatment for neovascular age-related macular degeneration: reasonable expectations of physicians and patients |
| title_fullStr | Treatment for neovascular age-related macular degeneration: reasonable expectations of physicians and patients |
| title_full_unstemmed | Treatment for neovascular age-related macular degeneration: reasonable expectations of physicians and patients |
| title_short | Treatment for neovascular age-related macular degeneration: reasonable expectations of physicians and patients |
| title_sort | treatment for neovascular age related macular degeneration reasonable expectations of physicians and patients |
| url | http://clinopht.com/upload/iblock/fb9/fb9619ee072c2e60e9c880a2d52da754.pdf |
| work_keys_str_mv | AT abdurasov treatmentforneovascularagerelatedmaculardegenerationreasonableexpectationsofphysiciansandpatients |