Immunologists' Perspectives on Monogenic Inflammatory Bowel Diseases
Inflammatory bowel diseases (IBD) encompass a group of chronic inflammatory disorders primarily impacting the gastrointestinal system, and they may also affect other organ systems. While common forms of IBD typically arise from multifactorial causes, there exists a subset of patients with single gen...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-04-01
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| Series: | Turkish Journal of Immunology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-09327 |
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| _version_ | 1841525394635751424 |
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| author | Maryiam Jama Ali Osman Emine Selva Aydoğdu Rafah Mackeh Ahmet Özen Bernice Lo |
| author_facet | Maryiam Jama Ali Osman Emine Selva Aydoğdu Rafah Mackeh Ahmet Özen Bernice Lo |
| author_sort | Maryiam Jama Ali Osman |
| collection | DOAJ |
| description | Inflammatory bowel diseases (IBD) encompass a group of chronic inflammatory disorders primarily impacting the gastrointestinal system, and they may also affect other organ systems. While common forms of IBD typically arise from multifactorial causes, there exists a subset of patients with single gene defects known as monogenic IBD (mIBD). Over 100 genes have been associated with mIBD, spanning various biological pathways which affect various tissues; the immune system is the most commonly involved, but more rarely, the intestinal epithelium is the primarily affected compartment. Timely diagnosis hinges on awareness and the application of contemporary molecular techniques. Due to the diverse range of causes, managing mIBD requires a multidisciplinary approach. Conventional treatments often fall short, necessitating a personalized strategy that considers the multifaceted nature of mIBD presentations and the diverse etiologic factors. In recent times, novel therapies have emerged, targeting specific causative genes or affected pathways. This discussion delves into the fundamental aspects of mIBD, with particular emphasis on recent breakthroughs in the field, encompassing newly identified gene defects and innovative management strategies. |
| format | Article |
| id | doaj-art-978d77cd64aa48f9b83ce5c0876f4b2c |
| institution | Kabale University |
| issn | 1301-109X 2147-8325 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Immunology |
| spelling | doaj-art-978d77cd64aa48f9b83ce5c0876f4b2c2025-01-17T13:55:52ZengGalenos Publishing HouseTurkish Journal of Immunology1301-109X2147-83252024-04-0112Suppl 1173610.4274/tji.galenos.2023.09327TJI-09327Immunologists' Perspectives on Monogenic Inflammatory Bowel DiseasesMaryiam Jama Ali Osman0Emine Selva Aydoğdu1Rafah Mackeh2Ahmet Özen3Bernice Lo4Hamad Bin Khalifa University Faculty of Medicine, College of Health and Life Sciences, Doha, QatarMarmara University Faculty of Medicine, İstanbul, TurkeyResearch Branch, Sidra Medicine, Doha, QatarMarmara University Faculty of Medicine, Department of Pediatrics, Division of Allergy and Immunology, İstanbul, TurkeyResearch Branch, Sidra Medicine, Doha, QatarInflammatory bowel diseases (IBD) encompass a group of chronic inflammatory disorders primarily impacting the gastrointestinal system, and they may also affect other organ systems. While common forms of IBD typically arise from multifactorial causes, there exists a subset of patients with single gene defects known as monogenic IBD (mIBD). Over 100 genes have been associated with mIBD, spanning various biological pathways which affect various tissues; the immune system is the most commonly involved, but more rarely, the intestinal epithelium is the primarily affected compartment. Timely diagnosis hinges on awareness and the application of contemporary molecular techniques. Due to the diverse range of causes, managing mIBD requires a multidisciplinary approach. Conventional treatments often fall short, necessitating a personalized strategy that considers the multifaceted nature of mIBD presentations and the diverse etiologic factors. In recent times, novel therapies have emerged, targeting specific causative genes or affected pathways. This discussion delves into the fundamental aspects of mIBD, with particular emphasis on recent breakthroughs in the field, encompassing newly identified gene defects and innovative management strategies.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-09327inflammatory bowel diseasesmonogenic defectsimmune systemmultidisciplinary approachpersonalized medicine |
| spellingShingle | Maryiam Jama Ali Osman Emine Selva Aydoğdu Rafah Mackeh Ahmet Özen Bernice Lo Immunologists' Perspectives on Monogenic Inflammatory Bowel Diseases Turkish Journal of Immunology inflammatory bowel diseases monogenic defects immune system multidisciplinary approach personalized medicine |
| title | Immunologists' Perspectives on Monogenic Inflammatory Bowel Diseases |
| title_full | Immunologists' Perspectives on Monogenic Inflammatory Bowel Diseases |
| title_fullStr | Immunologists' Perspectives on Monogenic Inflammatory Bowel Diseases |
| title_full_unstemmed | Immunologists' Perspectives on Monogenic Inflammatory Bowel Diseases |
| title_short | Immunologists' Perspectives on Monogenic Inflammatory Bowel Diseases |
| title_sort | immunologists perspectives on monogenic inflammatory bowel diseases |
| topic | inflammatory bowel diseases monogenic defects immune system multidisciplinary approach personalized medicine |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-09327 |
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