Frequency of weight and body composition increases in advanced non‐small cell lung cancer patients during first line therapy
Abstract Background The primary objective of this study was to assess the frequency of body composition increases and their relationships to changes in body weight in two cohorts of real world, treatment‐naïve, advanced non‐small cell lung cancer (NSCLC) patients. One cohort received the current sta...
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Wiley
2024-12-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
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| Online Access: | https://doi.org/10.1002/jcsm.13534 |
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| author | Philip Bonomi Hita Moudgalya Sandra L. Gomez Palmi Shah Sanjib Basu Marta Batus Levi B. Martinka Ahmed Abdelkader Iphigenia Tzameli Sonia Cobain Susie Collins Edmund J. Keliher Danna M. Breen Roberto A. Calle Mary Jo Fidler Jeffrey A. Borgia |
| author_facet | Philip Bonomi Hita Moudgalya Sandra L. Gomez Palmi Shah Sanjib Basu Marta Batus Levi B. Martinka Ahmed Abdelkader Iphigenia Tzameli Sonia Cobain Susie Collins Edmund J. Keliher Danna M. Breen Roberto A. Calle Mary Jo Fidler Jeffrey A. Borgia |
| author_sort | Philip Bonomi |
| collection | DOAJ |
| description | Abstract Background The primary objective of this study was to assess the frequency of body composition increases and their relationships to changes in body weight in two cohorts of real world, treatment‐naïve, advanced non‐small cell lung cancer (NSCLC) patients. One cohort received the current standard of care (CSOC), which consisted of immunotherapy and newer chemotherapy regimens, and the other cohort was treated with the former standard of care (FSOC), consisting only of older platinum‐containing regimens. Methods CSOC (n = 106) and FSOC (n = 88) cohorts of advanced NSCLC patients were included in this study. Weights were collected at each clinical visit, and body composition analysis from routine chest computed tomography via automated segmentation software assessed at baseline and at 6 and 12 weeks. Standard statistical methods were used to calculate relationships between changes in weight and in body composition. Results The CSOC cohort contained 106 stage IV NSCLC patients treated between 16/12/2014 and 22/10/2020 while the FSOC cohort contained 88 stage III/IV NSCLC patients treated between 16/6/2006 and 18/11/2014. While each cohort exhibited decreases in median weight, body mass index (BMI), mean skeletal muscle index (SMI) and subcutaneous adipose tissue index (SATI) at the 6 and 12 week time points, a subset of patients experienced increases in these parameters. Using a threshold of ≥2.5% increase for weight, BMI, SMI, and SATI at the 12 week time point, both cohorts showed similar (20.5% and 27.3%) increases in these parameters. With a cut point of ≥5% increase at 12 weeks follow‐up, 8.0% to 25.0% of the patients gained ≥5% in weight, BMI, SMI and SATI. Comparing these results in each cohort showed no significant differences. Pearson coefficients for weight change related to changes in SMI and SATI at 6 and 12 weeks ranged from 0.31 to 0.58 with all P values <0.02. Pearson coefficients for weight change at 12 weeks related to changes in VATI and IMATI ranged from 0.26 to 0.47 with all P values <0.05. Comparison of Pearson coefficients for each cohort showed no significant differences. Conclusions Although decreases in median weight, BMI, SMI and SATI were observed in both cohorts, similar percentage of patients in each cohort experienced increases in these parameters. These findings, plus the positive correlations between longitudinal measurements of weight, muscle mass and adipose tissue, indicate that weight gain in these patients involves increases in both muscle mass and adipose tissue. Upon validation, these findings could have implications for clinical trial design and for translational research in cancer cachexia. |
| format | Article |
| id | doaj-art-9783cab46df946fea677b29c1671a54e |
| institution | Kabale University |
| issn | 2190-5991 2190-6009 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
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| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj-art-9783cab46df946fea677b29c1671a54e2024-12-12T02:31:37ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092024-12-011562311232210.1002/jcsm.13534Frequency of weight and body composition increases in advanced non‐small cell lung cancer patients during first line therapyPhilip Bonomi0Hita Moudgalya1Sandra L. Gomez2Palmi Shah3Sanjib Basu4Marta Batus5Levi B. Martinka6Ahmed Abdelkader7Iphigenia Tzameli8Sonia Cobain9Susie Collins10Edmund J. Keliher11Danna M. Breen12Roberto A. Calle13Mary Jo Fidler14Jeffrey A. Borgia15Division of Hematology/Oncology Rush University Medical Center Chicago IL USADepartment of Anatomy and Cell Biology Rush University Medical Center Chicago IL USADepartment of Clinical Nutrition Rush University Medical Center Chicago IL USADepartment of Radiology Rush University Medical Center Chicago IL USABiostatistics, School of Public Health University of Illinois Chicago Chicago IL USADivision of Hematology/Oncology Rush University Medical Center Chicago IL USADepartment of Anatomy and Cell Biology Rush University Medical Center Chicago IL USADepartment of Anatomy and Cell Biology Rush University Medical Center Chicago IL USAInternal Medicine Research Unit Pfizer Inc. Cambridge MA USAGlobal Biometrics and Data Management Pfizer R&D UK Ltd Sandwich UKGlobal Biometrics and Data Management Pfizer R&D UK Ltd Sandwich UKEarly Clinical Development Pfizer Inc. Cambridge MA USAInternal Medicine Research Unit Pfizer Inc. Cambridge MA USAInternal Medicine Research Unit Pfizer Inc. Cambridge MA USADivision of Hematology/Oncology Rush University Medical Center Chicago IL USADepartment of Anatomy and Cell Biology Rush University Medical Center Chicago IL USAAbstract Background The primary objective of this study was to assess the frequency of body composition increases and their relationships to changes in body weight in two cohorts of real world, treatment‐naïve, advanced non‐small cell lung cancer (NSCLC) patients. One cohort received the current standard of care (CSOC), which consisted of immunotherapy and newer chemotherapy regimens, and the other cohort was treated with the former standard of care (FSOC), consisting only of older platinum‐containing regimens. Methods CSOC (n = 106) and FSOC (n = 88) cohorts of advanced NSCLC patients were included in this study. Weights were collected at each clinical visit, and body composition analysis from routine chest computed tomography via automated segmentation software assessed at baseline and at 6 and 12 weeks. Standard statistical methods were used to calculate relationships between changes in weight and in body composition. Results The CSOC cohort contained 106 stage IV NSCLC patients treated between 16/12/2014 and 22/10/2020 while the FSOC cohort contained 88 stage III/IV NSCLC patients treated between 16/6/2006 and 18/11/2014. While each cohort exhibited decreases in median weight, body mass index (BMI), mean skeletal muscle index (SMI) and subcutaneous adipose tissue index (SATI) at the 6 and 12 week time points, a subset of patients experienced increases in these parameters. Using a threshold of ≥2.5% increase for weight, BMI, SMI, and SATI at the 12 week time point, both cohorts showed similar (20.5% and 27.3%) increases in these parameters. With a cut point of ≥5% increase at 12 weeks follow‐up, 8.0% to 25.0% of the patients gained ≥5% in weight, BMI, SMI and SATI. Comparing these results in each cohort showed no significant differences. Pearson coefficients for weight change related to changes in SMI and SATI at 6 and 12 weeks ranged from 0.31 to 0.58 with all P values <0.02. Pearson coefficients for weight change at 12 weeks related to changes in VATI and IMATI ranged from 0.26 to 0.47 with all P values <0.05. Comparison of Pearson coefficients for each cohort showed no significant differences. Conclusions Although decreases in median weight, BMI, SMI and SATI were observed in both cohorts, similar percentage of patients in each cohort experienced increases in these parameters. These findings, plus the positive correlations between longitudinal measurements of weight, muscle mass and adipose tissue, indicate that weight gain in these patients involves increases in both muscle mass and adipose tissue. Upon validation, these findings could have implications for clinical trial design and for translational research in cancer cachexia.https://doi.org/10.1002/jcsm.13534body compositionbody weightcancer cachexiachemotherapyimmunotherapynon‐small cell lung cancer |
| spellingShingle | Philip Bonomi Hita Moudgalya Sandra L. Gomez Palmi Shah Sanjib Basu Marta Batus Levi B. Martinka Ahmed Abdelkader Iphigenia Tzameli Sonia Cobain Susie Collins Edmund J. Keliher Danna M. Breen Roberto A. Calle Mary Jo Fidler Jeffrey A. Borgia Frequency of weight and body composition increases in advanced non‐small cell lung cancer patients during first line therapy Journal of Cachexia, Sarcopenia and Muscle body composition body weight cancer cachexia chemotherapy immunotherapy non‐small cell lung cancer |
| title | Frequency of weight and body composition increases in advanced non‐small cell lung cancer patients during first line therapy |
| title_full | Frequency of weight and body composition increases in advanced non‐small cell lung cancer patients during first line therapy |
| title_fullStr | Frequency of weight and body composition increases in advanced non‐small cell lung cancer patients during first line therapy |
| title_full_unstemmed | Frequency of weight and body composition increases in advanced non‐small cell lung cancer patients during first line therapy |
| title_short | Frequency of weight and body composition increases in advanced non‐small cell lung cancer patients during first line therapy |
| title_sort | frequency of weight and body composition increases in advanced non small cell lung cancer patients during first line therapy |
| topic | body composition body weight cancer cachexia chemotherapy immunotherapy non‐small cell lung cancer |
| url | https://doi.org/10.1002/jcsm.13534 |
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