Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases
Abstract As an important element of the human body, iron participates in numerous physiological and biochemical reactions. In the past decade, ferroptosis (a form of iron-dependent regulated cell death) has been reported to contribute to the pathogenesis and progression of various diseases. The stab...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Clinical Epigenetics |
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| Online Access: | https://doi.org/10.1186/s13148-024-01809-5 |
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| author | Chunlu Jing Yupeng Wu Yuzhu Zhang Zaihan Zhu Yong Zhang Zhen Liu Dandan Sun |
| author_facet | Chunlu Jing Yupeng Wu Yuzhu Zhang Zaihan Zhu Yong Zhang Zhen Liu Dandan Sun |
| author_sort | Chunlu Jing |
| collection | DOAJ |
| description | Abstract As an important element of the human body, iron participates in numerous physiological and biochemical reactions. In the past decade, ferroptosis (a form of iron-dependent regulated cell death) has been reported to contribute to the pathogenesis and progression of various diseases. The stability of iron in cardiomyocytes is crucial for the maintenance of normal physiological cardiac activity. Ferroptosis has been detected in many cardiovascular diseases (CVDs), including coronary heart disease, myocardial ischemia–reperfusion injury, heart failure, and chemotherapy-induced myocardial damage. In cardiomyocytes, epigenetic regulation and post-translational modifications regulate the expression of ferroptosis-related factors, maintain iron homeostasis, and participate in the progression of CVDs. Currently, there is no detailed mechanism to explain the relationship between epigenetic regulation and ferroptosis in CVDs. In this review, we provide an initial summary of the core mechanisms of ferroptosis in cardiomyocytes, with first focus on the epigenetic regulation and expression of ferroptosis-related factors in the context of common cardiovascular diseases. We anticipate that the new insights into the pathogenesis of CVDs provided here will inspire the development of clinical interventions to specifically target the active sites of these factors, reducing the harmfulness of ferroptosis to human health. |
| format | Article |
| id | doaj-art-976457948c7f46469ac640e8918dfc42 |
| institution | Kabale University |
| issn | 1868-7083 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj-art-976457948c7f46469ac640e8918dfc422025-01-12T12:28:35ZengBMCClinical Epigenetics1868-70832025-01-0117111610.1186/s13148-024-01809-5Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseasesChunlu Jing0Yupeng Wu1Yuzhu Zhang2Zaihan Zhu3Yong Zhang4Zhen Liu5Dandan Sun6Department of Ultrasound, The People’s Hospital of China Medical University, The People’s Hospital of Liaoning ProvinceDepartment of Neurosurgery, The People’s Hospital of China Medical University, The People’s Hospital of Liaoning ProvinceDepartment of Ultrasound, The People’s Hospital of China Medical University, The People’s Hospital of Liaoning ProvinceDepartment of Ultrasound, The People’s Hospital of China Medical University, The People’s Hospital of Liaoning ProvinceDepartment of Urology, The People’s Hospital of Liaoning Province, The People’s Hospital of China Medical UniversityDepartment of Urology, The People’s Hospital of Liaoning Province, The People’s Hospital of China Medical UniversityDepartment of Ultrasound, The People’s Hospital of China Medical University, The People’s Hospital of Liaoning ProvinceAbstract As an important element of the human body, iron participates in numerous physiological and biochemical reactions. In the past decade, ferroptosis (a form of iron-dependent regulated cell death) has been reported to contribute to the pathogenesis and progression of various diseases. The stability of iron in cardiomyocytes is crucial for the maintenance of normal physiological cardiac activity. Ferroptosis has been detected in many cardiovascular diseases (CVDs), including coronary heart disease, myocardial ischemia–reperfusion injury, heart failure, and chemotherapy-induced myocardial damage. In cardiomyocytes, epigenetic regulation and post-translational modifications regulate the expression of ferroptosis-related factors, maintain iron homeostasis, and participate in the progression of CVDs. Currently, there is no detailed mechanism to explain the relationship between epigenetic regulation and ferroptosis in CVDs. In this review, we provide an initial summary of the core mechanisms of ferroptosis in cardiomyocytes, with first focus on the epigenetic regulation and expression of ferroptosis-related factors in the context of common cardiovascular diseases. We anticipate that the new insights into the pathogenesis of CVDs provided here will inspire the development of clinical interventions to specifically target the active sites of these factors, reducing the harmfulness of ferroptosis to human health.https://doi.org/10.1186/s13148-024-01809-5Cardiovascular diseasesFerroptosisEpigenetic regulationPost-translation modification |
| spellingShingle | Chunlu Jing Yupeng Wu Yuzhu Zhang Zaihan Zhu Yong Zhang Zhen Liu Dandan Sun Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases Clinical Epigenetics Cardiovascular diseases Ferroptosis Epigenetic regulation Post-translation modification |
| title | Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases |
| title_full | Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases |
| title_fullStr | Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases |
| title_full_unstemmed | Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases |
| title_short | Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases |
| title_sort | epigenetic regulation and post translational modifications of ferroptosis related factors in cardiovascular diseases |
| topic | Cardiovascular diseases Ferroptosis Epigenetic regulation Post-translation modification |
| url | https://doi.org/10.1186/s13148-024-01809-5 |
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