Sepsis-Induced Coagulopathy as a Risk for Postoperative Arterial Thrombosis: A Case Report
Background: Venous thromboembolic disease and arterial thrombosis are recognized as common causes of hospital mortality, especially in postoperative patients, those who are immobilized, and individuals with sepsis. Coagulopathy is a significant factor due to the interaction between inflammation and...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fakultas Kedokteran, Universitas Diponegoro
2025-03-01
|
| Series: | JAI (Jurnal Anestesiologi Indonesia) |
| Subjects: | |
| Online Access: | https://ejournal.undip.ac.id/index.php/janesti/article/view/57473 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background: Venous thromboembolic disease and arterial thrombosis are recognized as common causes of hospital mortality, especially in postoperative patients, those who are immobilized, and individuals with sepsis. Coagulopathy is a significant factor due to the interaction between inflammation and coagulation, stemming from widespread endothelial damage.
Case: We report manifestations of sepsis-induced coagulopathy (SIC) in a 64-year-old woman who was treated at the intensive care unit (ICU) of RSUD Dr. Moewardi with peripheral arterial disease. The patient was treated for 20 days in the ICU with a multidisciplinary approach. The patient's clinical outcome was good and planned for follow-up during outpatient care.
Discussion: Thrombosis and inflammation are distinct yet closely interconnected physiological processes. In a normal physiological context, the activation of the coagulation system by inflammation is a component of the body's defense mechanism against pathogens, aiming to restrict their spread within the bloodstream. This protective response involves the interaction between innate immune cells and platelets.
Conclusion: By gaining a deeper insight into sepsis-associated coagulopathy (microthrombopathy), we can develop effective treatments that specifically target the microthrombotic pathway involved in endothelial damage. |
|---|---|
| ISSN: | 2337-5124 2089-970X |