A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline

A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline

Abstract A hallmark of aging is chronic systemic inflammation, which is exacerbated by the hypersecretory aging phenotype known as the senescence-associated secretory phenotype (SASP). How the SASP is initiated to accelerate tissue inflammation and aging is an outstanding question in aging biology....

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Main Authors: Haozheng Li, Yuanming Zheng, Chunlei Yuan, Jiayi Wang, Xiaying Zhao, Ming Yang, Defei Xiong, Yenan Yang, Yunpeng Dai, Yiming Gao, Yuqi Wang, Lei Xue, Gang Wang
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-025-00820-1
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