Photo-curing hyaluronic acid-Janus antibacterial packs as O2 generator precisely modulate the infectious microenvironment for antibiotic-free periodontal therapy
Periodontal disease stands the leading cause of tooth loss in adults. While scaling and root planning is considered the “gold standard” treatment, it is often insufficient in efficiently eliminating anaerobic bacteria from deep periodontal pockets. In this work, an antibiotic-free and photo-curing h...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004666 |
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| author | Runxiu Wei Gaojie Li Yuying Huang Linjing Mi Jiamin Wu Huan Huang Na Yin Yuling Chen Qiang Yang Wenjun Zhang Bingzhi Sun Ran Sun Ling Guo Min Feng |
| author_facet | Runxiu Wei Gaojie Li Yuying Huang Linjing Mi Jiamin Wu Huan Huang Na Yin Yuling Chen Qiang Yang Wenjun Zhang Bingzhi Sun Ran Sun Ling Guo Min Feng |
| author_sort | Runxiu Wei |
| collection | DOAJ |
| description | Periodontal disease stands the leading cause of tooth loss in adults. While scaling and root planning is considered the “gold standard” treatment, it is often insufficient in efficiently eliminating anaerobic bacteria from deep periodontal pockets. In this work, an antibiotic-free and photo-curing hyaluronic acid-Janus (H-Janus) antibacterial pack was developed to inhibit the growth and colonization of residual bacteria within the pockets for reducing the recurrence of periodontitis. Our results demonstrated that a 4 wt% precursor solution of the antibacterial packs could be molded into various shapes by exposure to UV irradiation for less than 1 min, allowing the packs to seamlessly fill the irregular spaces of periodontal pockets. In vitro studies showed that the antibacterial packs gradually released lauric acid and oxygen over 7 days, exhibiting significant anti-biofilm effects against both aerobic and anaerobic bacteria. Notably, animal experiments confirmed that H-Janus antibacterial packs markedly improved the clinical scores in rats with periodontitis by inhibiting bacterial growth, alleviating inflammation, and fostering the regeneration of periodontal tissues. In light of their precise elimination of bacterial colonization and modulation of the infectious microenvironment, the H-Janus antibacterial packs show promising therapeutic potential for preventing the recurrence of periodontal pathogens following scaling and root planning. |
| format | Article |
| id | doaj-art-974043b2e5e64186888fe1bb78f69a9c |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-974043b2e5e64186888fe1bb78f69a9c2025-01-17T04:52:07ZengElsevierMaterials Today Bio2590-00642025-02-0130101405Photo-curing hyaluronic acid-Janus antibacterial packs as O2 generator precisely modulate the infectious microenvironment for antibiotic-free periodontal therapyRunxiu Wei0Gaojie Li1Yuying Huang2Linjing Mi3Jiamin Wu4Huan Huang5Na Yin6Yuling Chen7Qiang Yang8Wenjun Zhang9Bingzhi Sun10Ran Sun11Ling Guo12Min Feng13School of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, ChinaFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, CanadaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, ChinaKey Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China; Corresponding author.School of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, China; Corresponding author.Periodontal disease stands the leading cause of tooth loss in adults. While scaling and root planning is considered the “gold standard” treatment, it is often insufficient in efficiently eliminating anaerobic bacteria from deep periodontal pockets. In this work, an antibiotic-free and photo-curing hyaluronic acid-Janus (H-Janus) antibacterial pack was developed to inhibit the growth and colonization of residual bacteria within the pockets for reducing the recurrence of periodontitis. Our results demonstrated that a 4 wt% precursor solution of the antibacterial packs could be molded into various shapes by exposure to UV irradiation for less than 1 min, allowing the packs to seamlessly fill the irregular spaces of periodontal pockets. In vitro studies showed that the antibacterial packs gradually released lauric acid and oxygen over 7 days, exhibiting significant anti-biofilm effects against both aerobic and anaerobic bacteria. Notably, animal experiments confirmed that H-Janus antibacterial packs markedly improved the clinical scores in rats with periodontitis by inhibiting bacterial growth, alleviating inflammation, and fostering the regeneration of periodontal tissues. In light of their precise elimination of bacterial colonization and modulation of the infectious microenvironment, the H-Janus antibacterial packs show promising therapeutic potential for preventing the recurrence of periodontal pathogens following scaling and root planning.http://www.sciencedirect.com/science/article/pii/S2590006424004666PeriodontitisPhoto-curingH-Janus antibacterial packAerobic and anaerobic bacteria |
| spellingShingle | Runxiu Wei Gaojie Li Yuying Huang Linjing Mi Jiamin Wu Huan Huang Na Yin Yuling Chen Qiang Yang Wenjun Zhang Bingzhi Sun Ran Sun Ling Guo Min Feng Photo-curing hyaluronic acid-Janus antibacterial packs as O2 generator precisely modulate the infectious microenvironment for antibiotic-free periodontal therapy Materials Today Bio Periodontitis Photo-curing H-Janus antibacterial pack Aerobic and anaerobic bacteria |
| title | Photo-curing hyaluronic acid-Janus antibacterial packs as O2 generator precisely modulate the infectious microenvironment for antibiotic-free periodontal therapy |
| title_full | Photo-curing hyaluronic acid-Janus antibacterial packs as O2 generator precisely modulate the infectious microenvironment for antibiotic-free periodontal therapy |
| title_fullStr | Photo-curing hyaluronic acid-Janus antibacterial packs as O2 generator precisely modulate the infectious microenvironment for antibiotic-free periodontal therapy |
| title_full_unstemmed | Photo-curing hyaluronic acid-Janus antibacterial packs as O2 generator precisely modulate the infectious microenvironment for antibiotic-free periodontal therapy |
| title_short | Photo-curing hyaluronic acid-Janus antibacterial packs as O2 generator precisely modulate the infectious microenvironment for antibiotic-free periodontal therapy |
| title_sort | photo curing hyaluronic acid janus antibacterial packs as o2 generator precisely modulate the infectious microenvironment for antibiotic free periodontal therapy |
| topic | Periodontitis Photo-curing H-Janus antibacterial pack Aerobic and anaerobic bacteria |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004666 |
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