Prediction of CD8+ T cell infiltration in the tumor microenvironment of HGSOC patients
Abstract The tumor microenvironment (TME), particularly CD8+ T cell infiltration, critically influences high-grade serous ovarian cancer (HGSOC) progression and treatment response. The development and management of cancer depend heavily on CD8+ T cells. Identifying non-invasive predictors of TME imm...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-14720-7 |
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| author | Jia Mai Ling Yang YuXin Chen XiaoXu Zeng HongJian Xie XiaoJuan Liu |
| author_facet | Jia Mai Ling Yang YuXin Chen XiaoXu Zeng HongJian Xie XiaoJuan Liu |
| author_sort | Jia Mai |
| collection | DOAJ |
| description | Abstract The tumor microenvironment (TME), particularly CD8+ T cell infiltration, critically influences high-grade serous ovarian cancer (HGSOC) progression and treatment response. The development and management of cancer depend heavily on CD8+ T cells. Identifying non-invasive predictors of TME immune status is crucial. We investigated whether clinicopathologic characteristics and peripheral blood parameters could predict CD8+ T infiltration in TME of HGSOC. Two independent cohort were analyzed: (1) A multicenter tissue microarray (TMA) cohort of 105 epithelial ovarian cancer cases revealed that high CD8+ T cell density in tumor parenchyma, stroma, or whole tissue was significantly associated with good prognosis. (2) A retrospective cohort of 95 HGSOC patients from West China Second University Hospital (2016–2020) demonstrated that peripheral blood lymphocytes, globulin (GLB), lactate dehydrogenase (LDH), and low-density lipoprotein (LDL) correlated with CD8+ T cell infiltration in TME. These findings support non-invasive blood markers as predictors of tumor immune status and highlight chemotherapy’s role in enhancing CD8+ T cell recruitment. |
| format | Article |
| id | doaj-art-973f6727e9e24be08553be12d774c55a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-973f6727e9e24be08553be12d774c55a2025-08-24T11:25:51ZengNature PortfolioScientific Reports2045-23222025-08-0115111010.1038/s41598-025-14720-7Prediction of CD8+ T cell infiltration in the tumor microenvironment of HGSOC patientsJia Mai0Ling Yang1YuXin Chen2XiaoXu Zeng3HongJian Xie4XiaoJuan Liu5Department of Laboratory Medicine, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of EducationDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of EducationDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of EducationDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of EducationDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of EducationDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of EducationAbstract The tumor microenvironment (TME), particularly CD8+ T cell infiltration, critically influences high-grade serous ovarian cancer (HGSOC) progression and treatment response. The development and management of cancer depend heavily on CD8+ T cells. Identifying non-invasive predictors of TME immune status is crucial. We investigated whether clinicopathologic characteristics and peripheral blood parameters could predict CD8+ T infiltration in TME of HGSOC. Two independent cohort were analyzed: (1) A multicenter tissue microarray (TMA) cohort of 105 epithelial ovarian cancer cases revealed that high CD8+ T cell density in tumor parenchyma, stroma, or whole tissue was significantly associated with good prognosis. (2) A retrospective cohort of 95 HGSOC patients from West China Second University Hospital (2016–2020) demonstrated that peripheral blood lymphocytes, globulin (GLB), lactate dehydrogenase (LDH), and low-density lipoprotein (LDL) correlated with CD8+ T cell infiltration in TME. These findings support non-invasive blood markers as predictors of tumor immune status and highlight chemotherapy’s role in enhancing CD8+ T cell recruitment.https://doi.org/10.1038/s41598-025-14720-7High-grade serous ovarian cancerCD8+ T cellsTumor microenvironmentPeripheral blood parametersPrognosisSpatial distribution |
| spellingShingle | Jia Mai Ling Yang YuXin Chen XiaoXu Zeng HongJian Xie XiaoJuan Liu Prediction of CD8+ T cell infiltration in the tumor microenvironment of HGSOC patients Scientific Reports High-grade serous ovarian cancer CD8+ T cells Tumor microenvironment Peripheral blood parameters Prognosis Spatial distribution |
| title | Prediction of CD8+ T cell infiltration in the tumor microenvironment of HGSOC patients |
| title_full | Prediction of CD8+ T cell infiltration in the tumor microenvironment of HGSOC patients |
| title_fullStr | Prediction of CD8+ T cell infiltration in the tumor microenvironment of HGSOC patients |
| title_full_unstemmed | Prediction of CD8+ T cell infiltration in the tumor microenvironment of HGSOC patients |
| title_short | Prediction of CD8+ T cell infiltration in the tumor microenvironment of HGSOC patients |
| title_sort | prediction of cd8 t cell infiltration in the tumor microenvironment of hgsoc patients |
| topic | High-grade serous ovarian cancer CD8+ T cells Tumor microenvironment Peripheral blood parameters Prognosis Spatial distribution |
| url | https://doi.org/10.1038/s41598-025-14720-7 |
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