Decreased nitric oxide production is a novel therapeutic target for salt-induced nocturnal polyuria in aging

Decreased nitric oxide production is a novel therapeutic target for salt-induced nocturnal polyuria in aging

Abstract Nocturnal polyuria is a major cause of nocturia, which affects quality of life. Aging-related decreases in nitric oxide production have been reported to contribute to salt-induced nocturnal polyuria. We posited that enhanced nitric oxide production from exercise could mitigate salt-induced...

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Main Authors: Takahiro Imanaka, Kentaro Takezawa, Yuma Kujime, Hiroaki Kitakaze, Go Tsujimura, Sohei Kuribayashi, Yosuke Sekii, Norichika Ueda, Shinichiro Fukuhara, Hiroshi Kiuchi, Hiromitsu Negoro, Norio Nonomura
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Salt-induced nocturnal polyuria
Nitric oxide
Intrarenal renin-angiotensin system
Aging
Moderate-intensity exercise
Online Access:https://doi.org/10.1038/s41598-025-86526-6
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https://doi.org/10.1038/s41598-025-86526-6

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