The correlation between blood lipids and intrahepatic cholestasis syndrome during pregnancy
Background To analyse changes in lipid levels during the development of intrahepatic cholestasis of pregnancy (ICP) and identify new biomarkers for predicting ICP.Methods A retrospective case-control study was conducted to analyse 473 pregnant women who underwent regular prenatal examinations and de...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Journal of Obstetrics and Gynaecology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/01443615.2024.2369929 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841553165667794944 |
|---|---|
| author | Huibin Huang Juan Li Tianhua Chen Meidan Lu Gunsang Zhuoma Lijin Chen Yuebin Gan Huiming Ye |
| author_facet | Huibin Huang Juan Li Tianhua Chen Meidan Lu Gunsang Zhuoma Lijin Chen Yuebin Gan Huiming Ye |
| author_sort | Huibin Huang |
| collection | DOAJ |
| description | Background To analyse changes in lipid levels during the development of intrahepatic cholestasis of pregnancy (ICP) and identify new biomarkers for predicting ICP.Methods A retrospective case-control study was conducted to analyse 473 pregnant women who underwent regular prenatal examinations and delivered at the Women and Children’s Hospital, School of Medicine, Xiamen University, between June 2020 and June 2023, including 269 normal pregnancy controls and 204 pregnant women with cholestasis.Results Patients with ICP with gestational diabetes mellitus (GDM) have lower high-density lipoprotein (HDL) levels than in those without GDM. Total bile acid (TBA) levels were significantly higher in pregnant women with GDM than those without. The apolipoprotein A (APOA) level was lower in patients with ICP and hypothyroidism than those without hypothyroidism. TBA levels were significantly higher in pregnant women with hypothyroidism than those without. Triglyceride (TG) levels were significantly higher in patients with preeclampsia (PE) than those without. HDL and APOA levels were lower in women with ICP complicated by preterm delivery than those with normal delivery. The AUC (area under the curve) of the differential diagnosis of cholestasis of pregnancy for the APOA/APOB (apolipoprotein B) ratio was 0.727, with a sensitivity of 85.9% and specificity of 47.5%.Conclusions The results suggested that dyslipidaemia is associated with an increased risk of ICP and its complications. The timely detection of blood lipid and bile acid levels can assist in the diagnosis of ICP and effectively prevent ICP and other complications. |
| format | Article |
| id | doaj-art-972cffd13e8e4819a48779e7f7105428 |
| institution | Kabale University |
| issn | 0144-3615 1364-6893 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Obstetrics and Gynaecology |
| spelling | doaj-art-972cffd13e8e4819a48779e7f71054282025-01-09T12:13:17ZengTaylor & Francis GroupJournal of Obstetrics and Gynaecology0144-36151364-68932024-12-0144110.1080/01443615.2024.2369929The correlation between blood lipids and intrahepatic cholestasis syndrome during pregnancyHuibin Huang0Juan Li1Tianhua Chen2Meidan Lu3Gunsang Zhuoma4Lijin Chen5Yuebin Gan6Huiming Ye7Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen City, ChinaDepartment of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen City, ChinaDepartment of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen City, ChinaDepartment of obstetrics, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen City, ChinaSchool of Public Health, Xiamen University, Xiamen City, ChinaDepartment of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen City, ChinaDepartment of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen City, ChinaDepartment of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen City, ChinaBackground To analyse changes in lipid levels during the development of intrahepatic cholestasis of pregnancy (ICP) and identify new biomarkers for predicting ICP.Methods A retrospective case-control study was conducted to analyse 473 pregnant women who underwent regular prenatal examinations and delivered at the Women and Children’s Hospital, School of Medicine, Xiamen University, between June 2020 and June 2023, including 269 normal pregnancy controls and 204 pregnant women with cholestasis.Results Patients with ICP with gestational diabetes mellitus (GDM) have lower high-density lipoprotein (HDL) levels than in those without GDM. Total bile acid (TBA) levels were significantly higher in pregnant women with GDM than those without. The apolipoprotein A (APOA) level was lower in patients with ICP and hypothyroidism than those without hypothyroidism. TBA levels were significantly higher in pregnant women with hypothyroidism than those without. Triglyceride (TG) levels were significantly higher in patients with preeclampsia (PE) than those without. HDL and APOA levels were lower in women with ICP complicated by preterm delivery than those with normal delivery. The AUC (area under the curve) of the differential diagnosis of cholestasis of pregnancy for the APOA/APOB (apolipoprotein B) ratio was 0.727, with a sensitivity of 85.9% and specificity of 47.5%.Conclusions The results suggested that dyslipidaemia is associated with an increased risk of ICP and its complications. The timely detection of blood lipid and bile acid levels can assist in the diagnosis of ICP and effectively prevent ICP and other complications.https://www.tandfonline.com/doi/10.1080/01443615.2024.2369929Bile acidcomplicationslipidpregnancyrisk |
| spellingShingle | Huibin Huang Juan Li Tianhua Chen Meidan Lu Gunsang Zhuoma Lijin Chen Yuebin Gan Huiming Ye The correlation between blood lipids and intrahepatic cholestasis syndrome during pregnancy Journal of Obstetrics and Gynaecology Bile acid complications lipid pregnancy risk |
| title | The correlation between blood lipids and intrahepatic cholestasis syndrome during pregnancy |
| title_full | The correlation between blood lipids and intrahepatic cholestasis syndrome during pregnancy |
| title_fullStr | The correlation between blood lipids and intrahepatic cholestasis syndrome during pregnancy |
| title_full_unstemmed | The correlation between blood lipids and intrahepatic cholestasis syndrome during pregnancy |
| title_short | The correlation between blood lipids and intrahepatic cholestasis syndrome during pregnancy |
| title_sort | correlation between blood lipids and intrahepatic cholestasis syndrome during pregnancy |
| topic | Bile acid complications lipid pregnancy risk |
| url | https://www.tandfonline.com/doi/10.1080/01443615.2024.2369929 |
| work_keys_str_mv | AT huibinhuang thecorrelationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT juanli thecorrelationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT tianhuachen thecorrelationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT meidanlu thecorrelationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT gunsangzhuoma thecorrelationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT lijinchen thecorrelationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT yuebingan thecorrelationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT huimingye thecorrelationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT huibinhuang correlationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT juanli correlationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT tianhuachen correlationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT meidanlu correlationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT gunsangzhuoma correlationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT lijinchen correlationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT yuebingan correlationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy AT huimingye correlationbetweenbloodlipidsandintrahepaticcholestasissyndromeduringpregnancy |