The Expression Regulation and Cancer-Promoting Roles of RACGAP1

The Expression Regulation and Cancer-Promoting Roles of RACGAP1

RACGAP1 is a Rho-GTPase-activating protein originally discovered in male germ cells to inactivate Rac, RhoA and Cdc42 from the GTP-bound form to the GDP-bound form. GAP has traditionally been known as a tumor suppressor. However, studies increasingly suggest that overexpressed RACGAP1 activates Rac...

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Bibliographic Details
Main Authors: Jiacheng Lin, Yuhao Zhu, Zhaoping Lin, Jindong Yu, Xiaobing Lin, Weiyuan Lai, Beibei Tong, Liyan Xu, Enmin Li, Lin Long
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomolecules
Subjects:
RACGAP1
Rho-GTPases
ECT2
STAT3
Online Access:https://www.mdpi.com/2218-273X/15/1/3
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