Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy

Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy

Background: Developmental and epileptic encephalopathies (DEE) are rare but severe neurodevelopmental disorders characterised by early-onset seizures often combined with developmental delay, behavioural and cognitive deficits. Treatment for DEEs is currently limited to seizure control and provides n...

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Main Authors: Miaomiao Mao, Nikola Jancovski, Yafit Kushner, Lucas Teasdale, Phan Truong, Kun Zhou, Samuel Reid, Linghan Jia, Ye Htet Aung, Melody Li, Christopher A. Reid, Sean Byars, Ingrid Scheffer, Steven Petrou, Snezana Maljevic
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Neurobiology of Disease
Subjects:
M-channels
Genetic epilepsy
Mouse model
Neuronal excitability
Developmental dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612400384X
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