Can Nonfibrotic Nonalcoholic Steatohepatitis Be Effectively Identified by Supersonic Shear Imaging?
Supersonic shear imaging (SSI) is a relatively new technique to measure the elasticity of target tissues based on the shear wave propagation. The aim of this study was to evaluate the value of SSI in discriminating nonfibrotic nonalcoholic steatohepatitis (NASH) from the less severe nonalcoholic fat...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2019/2013674 |
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| author | Jiajia Yang Liwu Lin Ensheng Xue Dengke Hong Yan Yang Meifang Xu Zhikui Chen |
| author_facet | Jiajia Yang Liwu Lin Ensheng Xue Dengke Hong Yan Yang Meifang Xu Zhikui Chen |
| author_sort | Jiajia Yang |
| collection | DOAJ |
| description | Supersonic shear imaging (SSI) is a relatively new technique to measure the elasticity of target tissues based on the shear wave propagation. The aim of this study was to evaluate the value of SSI in discriminating nonfibrotic nonalcoholic steatohepatitis (NASH) from the less severe nonalcoholic fatty liver disease (NAFLD), NASH with fibrosis, and the normal liver, as well as the relationship between various NAFLD pathologic or biochemical findings and SSI liver elasticity. Rabbits with NAFLD of different degrees were subjected to SSI for liver elasticity measurement. Plasma was collected for biochemical examinations, and liver tissues were harvested for pathologic assessment. Results showed that liver elasticity of rabbits with nonfibrotic NASH was significantly different from that of rabbits with simple steatosis, borderline, NASH with fibrosis, and normal liver (P<0.05) and the areas under the receiver operating characteristic curve of SSI for predicting nonfibrotic NASH and NASH with fibrosis were 0.997 and 0.967, respectively, and the optimal cutoff values were 10.17 kPa and 12.82 kPa, respectively. Multivariate analysis showed that only fibrosis and inflammation were the independent factors affecting liver elasticity of NAFLD (P≤0.001), while inflammation, steatosis, and ballooning degeneration were all independently related to liver elasticity in rabbits without fibrosis (P<0.01). In addition, alanine aminotransferase was the only biochemical factor independently related to liver elasticity (P≤0.001). Our results indicate that SSI can effectively identify nonfibrotic NASH in rabbits based on the difference in liver elasticity and the difference is related to the various pathologic changes, including fibrosis, inflammation, steatosis, and ballooning degeneration. |
| format | Article |
| id | doaj-art-96fcedb1c3174396aba37fb2284c0e6c |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-96fcedb1c3174396aba37fb2284c0e6c2025-02-03T05:47:27ZengWileyAnalytical Cellular Pathology2210-71772210-71852019-01-01201910.1155/2019/20136742013674Can Nonfibrotic Nonalcoholic Steatohepatitis Be Effectively Identified by Supersonic Shear Imaging?Jiajia Yang0Liwu Lin1Ensheng Xue2Dengke Hong3Yan Yang4Meifang Xu5Zhikui Chen6Department of Ultrasound, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Ultrasound, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Ultrasound, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Vascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Ultrasound, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Ultrasound, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaSupersonic shear imaging (SSI) is a relatively new technique to measure the elasticity of target tissues based on the shear wave propagation. The aim of this study was to evaluate the value of SSI in discriminating nonfibrotic nonalcoholic steatohepatitis (NASH) from the less severe nonalcoholic fatty liver disease (NAFLD), NASH with fibrosis, and the normal liver, as well as the relationship between various NAFLD pathologic or biochemical findings and SSI liver elasticity. Rabbits with NAFLD of different degrees were subjected to SSI for liver elasticity measurement. Plasma was collected for biochemical examinations, and liver tissues were harvested for pathologic assessment. Results showed that liver elasticity of rabbits with nonfibrotic NASH was significantly different from that of rabbits with simple steatosis, borderline, NASH with fibrosis, and normal liver (P<0.05) and the areas under the receiver operating characteristic curve of SSI for predicting nonfibrotic NASH and NASH with fibrosis were 0.997 and 0.967, respectively, and the optimal cutoff values were 10.17 kPa and 12.82 kPa, respectively. Multivariate analysis showed that only fibrosis and inflammation were the independent factors affecting liver elasticity of NAFLD (P≤0.001), while inflammation, steatosis, and ballooning degeneration were all independently related to liver elasticity in rabbits without fibrosis (P<0.01). In addition, alanine aminotransferase was the only biochemical factor independently related to liver elasticity (P≤0.001). Our results indicate that SSI can effectively identify nonfibrotic NASH in rabbits based on the difference in liver elasticity and the difference is related to the various pathologic changes, including fibrosis, inflammation, steatosis, and ballooning degeneration.http://dx.doi.org/10.1155/2019/2013674 |
| spellingShingle | Jiajia Yang Liwu Lin Ensheng Xue Dengke Hong Yan Yang Meifang Xu Zhikui Chen Can Nonfibrotic Nonalcoholic Steatohepatitis Be Effectively Identified by Supersonic Shear Imaging? Analytical Cellular Pathology |
| title | Can Nonfibrotic Nonalcoholic Steatohepatitis Be Effectively Identified by Supersonic Shear Imaging? |
| title_full | Can Nonfibrotic Nonalcoholic Steatohepatitis Be Effectively Identified by Supersonic Shear Imaging? |
| title_fullStr | Can Nonfibrotic Nonalcoholic Steatohepatitis Be Effectively Identified by Supersonic Shear Imaging? |
| title_full_unstemmed | Can Nonfibrotic Nonalcoholic Steatohepatitis Be Effectively Identified by Supersonic Shear Imaging? |
| title_short | Can Nonfibrotic Nonalcoholic Steatohepatitis Be Effectively Identified by Supersonic Shear Imaging? |
| title_sort | can nonfibrotic nonalcoholic steatohepatitis be effectively identified by supersonic shear imaging |
| url | http://dx.doi.org/10.1155/2019/2013674 |
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