Central Diabetes Insipidus in Acute Myeloid Leukemia with Cytogenetic Abnormality of 9q34 Deletion
Acute myeloid leukemia (AML) is rarely associated with central diabetes insipidus (CDI) with unclear underlying pathophysiological mechanisms. The most commonly reported cytogenetic abnormality in cases of AML-associated CDI is monosomy 7, followed by chromosome 3 abnormalities. We report a case of...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2024-07-01
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| Series: | Oman Medical Journal |
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| Online Access: | https://omjournal.org/articleDetails.aspx?coType=1&aId=3808 |
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| author | Majd Farajallah Fatima Alkaabi Arif Alam Raya Almazrouei |
| author_facet | Majd Farajallah Fatima Alkaabi Arif Alam Raya Almazrouei |
| author_sort | Majd Farajallah |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) is rarely associated with central diabetes insipidus (CDI) with unclear underlying pathophysiological mechanisms. The most commonly reported cytogenetic abnormality in cases of AML-associated CDI is monosomy 7, followed by chromosome 3 abnormalities. We report a case of a woman with newly diagnosed AML with 9q34 deletion (ABL1 gene region), who developed symptoms of polyuria and polydipsia with an investigation confirming CDI. This is the first reported case of cytogenetic abnormality of 9q34 deletion (ABL1 gene region) in AML with CDI. |
| format | Article |
| id | doaj-art-96e4097e1c5841ff93a9709bb7d87bce |
| institution | Kabale University |
| issn | 1999-768X 2070-5204 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj-art-96e4097e1c5841ff93a9709bb7d87bce2025-01-02T10:29:32ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042024-07-01394e661e66110.5001/omj.2024.22Central Diabetes Insipidus in Acute Myeloid Leukemia with Cytogenetic Abnormality of 9q34 DeletionMajd Farajallah0Fatima Alkaabi1Arif Alam2Raya Almazrouei3Department of Internal Medicine, Tawam Hospital, Al Ain, UAEDivision of Endocrinology, Tawam Hospital, Al Ain, UAEDepartment of Hematology and Oncology, Tawam Hospital, Al Ain, UAEInternal Medicine Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAEAcute myeloid leukemia (AML) is rarely associated with central diabetes insipidus (CDI) with unclear underlying pathophysiological mechanisms. The most commonly reported cytogenetic abnormality in cases of AML-associated CDI is monosomy 7, followed by chromosome 3 abnormalities. We report a case of a woman with newly diagnosed AML with 9q34 deletion (ABL1 gene region), who developed symptoms of polyuria and polydipsia with an investigation confirming CDI. This is the first reported case of cytogenetic abnormality of 9q34 deletion (ABL1 gene region) in AML with CDI.https://omjournal.org/articleDetails.aspx?coType=1&aId=3808central diabetes insipidusacute myeloid leukemiapolyuriapolydipsiacytogeneticsunited arab emirates |
| spellingShingle | Majd Farajallah Fatima Alkaabi Arif Alam Raya Almazrouei Central Diabetes Insipidus in Acute Myeloid Leukemia with Cytogenetic Abnormality of 9q34 Deletion Oman Medical Journal central diabetes insipidus acute myeloid leukemia polyuria polydipsia cytogenetics united arab emirates |
| title | Central Diabetes Insipidus in Acute Myeloid Leukemia with Cytogenetic Abnormality of 9q34 Deletion |
| title_full | Central Diabetes Insipidus in Acute Myeloid Leukemia with Cytogenetic Abnormality of 9q34 Deletion |
| title_fullStr | Central Diabetes Insipidus in Acute Myeloid Leukemia with Cytogenetic Abnormality of 9q34 Deletion |
| title_full_unstemmed | Central Diabetes Insipidus in Acute Myeloid Leukemia with Cytogenetic Abnormality of 9q34 Deletion |
| title_short | Central Diabetes Insipidus in Acute Myeloid Leukemia with Cytogenetic Abnormality of 9q34 Deletion |
| title_sort | central diabetes insipidus in acute myeloid leukemia with cytogenetic abnormality of 9q34 deletion |
| topic | central diabetes insipidus acute myeloid leukemia polyuria polydipsia cytogenetics united arab emirates |
| url | https://omjournal.org/articleDetails.aspx?coType=1&aId=3808 |
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