Correlation of hair risperidone concentration and serum level among patients with schizophrenia
Background Risperidone (RSP) has a rapid onset in vivo, low dosage and high plasma protein binding rate, therefore therapeutic drug monitoring (TDM) is needed to ensure safety in clinical treatment. However, compared with blood, hair is non-invasive, safe, non-infectious and easy to transport and st...
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BMJ Publishing Group
2019-02-01
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| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/32/1/e100042.full |
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| author | Xiujia Sun Lihua Wang Fuzhong Yang Juanjuan Ren Ping Jiang Hongmei Liu Huafang Li Chunbo Li Chen Zhang |
| author_facet | Xiujia Sun Lihua Wang Fuzhong Yang Juanjuan Ren Ping Jiang Hongmei Liu Huafang Li Chunbo Li Chen Zhang |
| author_sort | Xiujia Sun |
| collection | DOAJ |
| description | Background Risperidone (RSP) has a rapid onset in vivo, low dosage and high plasma protein binding rate, therefore therapeutic drug monitoring (TDM) is needed to ensure safety in clinical treatment. However, compared with blood, hair is non-invasive, safe, non-infectious and easy to transport and store.Aims This study aims to investigate the correlations among the drug concentrations of RSP in hair and serum, which provides an experimental basis to explore hair as a novel biomaterial to meet the needs of clinical detection.Methods 34 patients with schizophrenia treated with RSP for more than 3 months were enrolled in this study. About 1 cm section of hair near the scalp was taken from the subjects, pretreated and detected by liquid chromatography-mass spectrometry. A correlation analysis was conducted among the drug concentrations in hair, the serum concentrations and the daily dosage. The data were analysed using SPSS 20.0 software.Results There was significant correlation between the hair concentration of RSP (two-tailed test, r=0.440, p=0.009) with the serum concentration of RSP, and the hair concentration of 9-hydroxyrisperidone (9-HR) with the serum concentration of 9-HR had no significant correlation (two-tailed test, r=−0.217, p=0.217); the total concentration of the RSP and 9-HR had no significant correlation between hair and serum (r=0.227, p=0.196). The dosage had no statistically significant correlation with the concentration of RSP in hair (r=0.207, p=0.241), 9-HR in hair (r=−0.194, p=0.271) and the total concentration of RSP and 9-HR in hair (r=0.188, p=0.288). There was no statistical correlation between the dosage and the concentration of RSP in serum (r=−0.059, p=0.741), but significant correlation between the dosage and 9-HR in serum (r=0.581 p<0.001) was found, and the correlation between the dosage and the total concentration of the two drugs RSP and 9-HR in serum was also significant (r=0.437, p=0.01).Conclusion The correlation analysis showed that the concentration of RSP in hair was statistically significant with the serum RSP concentration. In this study, we provided some experimental basis for hair as a new biomaterial to monitor the therapeutic drug concentration. |
| format | Article |
| id | doaj-art-96d247b7a683442492b65d7be0b3a701 |
| institution | Kabale University |
| issn | 2517-729X |
| language | English |
| publishDate | 2019-02-01 |
| publisher | BMJ Publishing Group |
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| series | General Psychiatry |
| spelling | doaj-art-96d247b7a683442492b65d7be0b3a7012024-11-08T10:15:08ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2019-02-0132110.1136/gpsych-2018-100042Correlation of hair risperidone concentration and serum level among patients with schizophreniaXiujia Sun0Lihua Wang1Fuzhong Yang2Juanjuan Ren3Ping Jiang4Hongmei Liu5Huafang Li6Chunbo Li7Chen Zhang82 Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China2 Department of Nursing, Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China2 Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200030, China2 Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China1 Neonatology, Shenzhen Luohu People`s Hospital, Shenzhen, Guangdong, ChinaShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDrug Clinical Trial Institution, Shanghai Mental Health Center, Shanghai, China5 Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China1 Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200030, ChinaBackground Risperidone (RSP) has a rapid onset in vivo, low dosage and high plasma protein binding rate, therefore therapeutic drug monitoring (TDM) is needed to ensure safety in clinical treatment. However, compared with blood, hair is non-invasive, safe, non-infectious and easy to transport and store.Aims This study aims to investigate the correlations among the drug concentrations of RSP in hair and serum, which provides an experimental basis to explore hair as a novel biomaterial to meet the needs of clinical detection.Methods 34 patients with schizophrenia treated with RSP for more than 3 months were enrolled in this study. About 1 cm section of hair near the scalp was taken from the subjects, pretreated and detected by liquid chromatography-mass spectrometry. A correlation analysis was conducted among the drug concentrations in hair, the serum concentrations and the daily dosage. The data were analysed using SPSS 20.0 software.Results There was significant correlation between the hair concentration of RSP (two-tailed test, r=0.440, p=0.009) with the serum concentration of RSP, and the hair concentration of 9-hydroxyrisperidone (9-HR) with the serum concentration of 9-HR had no significant correlation (two-tailed test, r=−0.217, p=0.217); the total concentration of the RSP and 9-HR had no significant correlation between hair and serum (r=0.227, p=0.196). The dosage had no statistically significant correlation with the concentration of RSP in hair (r=0.207, p=0.241), 9-HR in hair (r=−0.194, p=0.271) and the total concentration of RSP and 9-HR in hair (r=0.188, p=0.288). There was no statistical correlation between the dosage and the concentration of RSP in serum (r=−0.059, p=0.741), but significant correlation between the dosage and 9-HR in serum (r=0.581 p<0.001) was found, and the correlation between the dosage and the total concentration of the two drugs RSP and 9-HR in serum was also significant (r=0.437, p=0.01).Conclusion The correlation analysis showed that the concentration of RSP in hair was statistically significant with the serum RSP concentration. In this study, we provided some experimental basis for hair as a new biomaterial to monitor the therapeutic drug concentration.https://gpsych.bmj.com/content/32/1/e100042.full |
| spellingShingle | Xiujia Sun Lihua Wang Fuzhong Yang Juanjuan Ren Ping Jiang Hongmei Liu Huafang Li Chunbo Li Chen Zhang Correlation of hair risperidone concentration and serum level among patients with schizophrenia General Psychiatry |
| title | Correlation of hair risperidone concentration and serum level among patients with schizophrenia |
| title_full | Correlation of hair risperidone concentration and serum level among patients with schizophrenia |
| title_fullStr | Correlation of hair risperidone concentration and serum level among patients with schizophrenia |
| title_full_unstemmed | Correlation of hair risperidone concentration and serum level among patients with schizophrenia |
| title_short | Correlation of hair risperidone concentration and serum level among patients with schizophrenia |
| title_sort | correlation of hair risperidone concentration and serum level among patients with schizophrenia |
| url | https://gpsych.bmj.com/content/32/1/e100042.full |
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