Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture

Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture

Abstract Nuclear translocation of the transcription regulatory proteins yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) is a critical readout of cellular mechanotransduction. Recent experiments have demonstrated that cells on substrates with well‐defined nan...

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Bibliographic Details
Main Authors: Emmet A. Francis, Einollah Sarikhani, Vrund Patel, Dhivya Pushpa Meganathan, Leah Sadr, Anum Tahir, Zeinab Jahed, Padmini Rangamani
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
mechanoadaptation
mechanotransduction
nanotopography
nuclear transport
systems biophysics
Online Access:https://doi.org/10.1002/advs.202415029
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