Gynecological Insights into Lynch Syndrome—A Comprehensive Review of Cancer Screening and Prevention
Lynch syndrome, one of the most common genetic syndromes predisposing to cancer, is associated with a series of malignant conditions, among which the most frequent is colorectal cancer, but gynecologic cancers (especially endometrial) are also quite common. Despite the significant progress made in u...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/60/12/2013 |
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| author | Elena Chitoran Roxana-Elena Bohiltea Vlad Rotaru Cristiana-Elena Durdu Madalina-Nicoleta Mitroiu Laurentiu Simion |
| author_facet | Elena Chitoran Roxana-Elena Bohiltea Vlad Rotaru Cristiana-Elena Durdu Madalina-Nicoleta Mitroiu Laurentiu Simion |
| author_sort | Elena Chitoran |
| collection | DOAJ |
| description | Lynch syndrome, one of the most common genetic syndromes predisposing to cancer, is associated with a series of malignant conditions, among which the most frequent is colorectal cancer, but gynecologic cancers (especially endometrial) are also quite common. Despite the significant progress made in understanding this condition over time, there are still aspects in managing this condition that have not demonstrated clear benefits. This article aims to summarize the recommendations of international societies and present the latest developments in managing Lynch syndrome, focusing on gynecologic cancer screening and possible prevention strategies. Advances in genetic testing procedures and discoveries related to the association between oncological pathology frequency and the affected pathogenic variant type will probably lead to personalized medicine focused on the individual patient in the coming years. Although various screening methods for gynecological cancers in patients with Lynch syndrome have been used over time, they have not shown significant survival benefits. This highlights the need for studying and implementing new screening and diagnostic methods, which have been under investigation in recent years and are mentioned in this article. |
| format | Article |
| id | doaj-art-968ec3b0a18e444fb1f57509b035a2db |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-968ec3b0a18e444fb1f57509b035a2db2024-12-27T14:38:49ZengMDPI AGMedicina1010-660X1648-91442024-12-016012201310.3390/medicina60122013Gynecological Insights into Lynch Syndrome—A Comprehensive Review of Cancer Screening and PreventionElena Chitoran0Roxana-Elena Bohiltea1Vlad Rotaru2Cristiana-Elena Durdu3Madalina-Nicoleta Mitroiu4Laurentiu Simion5Medicine School, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaMedicine School, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaMedicine School, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaObstetrics, Gynecology and Neonatology Department, “Filantropia” Clinical Hospital, 011132 Bucharest, RomaniaObstetrics, Gynecology and Neonatology Department, “Filantropia” Clinical Hospital, 011132 Bucharest, RomaniaMedicine School, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaLynch syndrome, one of the most common genetic syndromes predisposing to cancer, is associated with a series of malignant conditions, among which the most frequent is colorectal cancer, but gynecologic cancers (especially endometrial) are also quite common. Despite the significant progress made in understanding this condition over time, there are still aspects in managing this condition that have not demonstrated clear benefits. This article aims to summarize the recommendations of international societies and present the latest developments in managing Lynch syndrome, focusing on gynecologic cancer screening and possible prevention strategies. Advances in genetic testing procedures and discoveries related to the association between oncological pathology frequency and the affected pathogenic variant type will probably lead to personalized medicine focused on the individual patient in the coming years. Although various screening methods for gynecological cancers in patients with Lynch syndrome have been used over time, they have not shown significant survival benefits. This highlights the need for studying and implementing new screening and diagnostic methods, which have been under investigation in recent years and are mentioned in this article.https://www.mdpi.com/1648-9144/60/12/2013Lynch syndromemutations of DNA mismatch repair genesMMR geneshigh-risk patientscancer screeninggynecological cancers |
| spellingShingle | Elena Chitoran Roxana-Elena Bohiltea Vlad Rotaru Cristiana-Elena Durdu Madalina-Nicoleta Mitroiu Laurentiu Simion Gynecological Insights into Lynch Syndrome—A Comprehensive Review of Cancer Screening and Prevention Medicina Lynch syndrome mutations of DNA mismatch repair genes MMR genes high-risk patients cancer screening gynecological cancers |
| title | Gynecological Insights into Lynch Syndrome—A Comprehensive Review of Cancer Screening and Prevention |
| title_full | Gynecological Insights into Lynch Syndrome—A Comprehensive Review of Cancer Screening and Prevention |
| title_fullStr | Gynecological Insights into Lynch Syndrome—A Comprehensive Review of Cancer Screening and Prevention |
| title_full_unstemmed | Gynecological Insights into Lynch Syndrome—A Comprehensive Review of Cancer Screening and Prevention |
| title_short | Gynecological Insights into Lynch Syndrome—A Comprehensive Review of Cancer Screening and Prevention |
| title_sort | gynecological insights into lynch syndrome a comprehensive review of cancer screening and prevention |
| topic | Lynch syndrome mutations of DNA mismatch repair genes MMR genes high-risk patients cancer screening gynecological cancers |
| url | https://www.mdpi.com/1648-9144/60/12/2013 |
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