Effects of ovarian steroids on oxidative stress in overiectomized rats
<b>Aim:</b> Determining the effects of combined or separate estrogen and progesterone administration on lipid peroxidation, antioxidative activity (AOA), β-carotene, vitamin A and C levels in overiectomized rats.<p> <b>Materials and Methods:</b> The study was c...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=854 |
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| author | Aziz Bulbul Recep Aslan H. Ahmet Celik Gulcan Avci Fatih Fidan |
| author_facet | Aziz Bulbul Recep Aslan H. Ahmet Celik Gulcan Avci Fatih Fidan |
| author_sort | Aziz Bulbul |
| collection | DOAJ |
| description | <b>Aim:</b> Determining the effects of combined or separate estrogen
and progesterone administration on lipid peroxidation,
antioxidative activity (AOA), β-carotene, vitamin A and
C levels in overiectomized rats.<p>
<b>Materials and Methods:</b> The study was conducted on 1
control and 3 trial groups each consisted of 10 overiectomized
rats. Control group received sesame oil while progesterone
group received 2 mg/rat/day progesterone, estrogen
group 10 mg/rat/day 17β-estradiol and estrogen +
progesteron group 10 mg/rat/day 17β-estradiol+ 2 mg/rat/
day progesterone for 10 days. Blood samples of rats were
collected under general anesthesia after 2 hours following
last administration and checked for malondialdehyde
(MDA), AOA, β-carotene, vitamin A, and C levels.<p>
<b>Results:</b> Whole blood MDA levels in estrogen group were
decreased as compared to control group while remained
same in others. Plasma AOA levels of estrogen and estrogen
+ progesterone groups were higher (p<0.05) than control
and progesterone groups. Plasma β-carotene levels were
decreased in all trial groups when compared to control.
Vitamin C levels of all groups were higher as compared to
control group and were highest in estrogen + progesterone
group.<p>
<b>Conclusion:</b> It can be concluded that estrogen decreases
lipid peroxidation and increases antioxidant capacity besides
effects positively the levels of antioxidant vitamins,
particularly showing that mentioned level of estrogen act
as an antioxidant. |
| format | Article |
| id | doaj-art-9683df8d7f2b4e35baa72d541a3fcda9 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-9683df8d7f2b4e35baa72d541a3fcda92025-01-03T01:36:14ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532829498854Effects of ovarian steroids on oxidative stress in overiectomized ratsAziz Bulbul0Recep Aslan1H. Ahmet Celik2Gulcan Avci3Fatih Fidan4Department of Physiology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, TurkeyDepartment of Physiology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, TurkeyDepartment of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, TurkeyDepartment of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, TurkeyDepartment of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey<b>Aim:</b> Determining the effects of combined or separate estrogen and progesterone administration on lipid peroxidation, antioxidative activity (AOA), β-carotene, vitamin A and C levels in overiectomized rats.<p> <b>Materials and Methods:</b> The study was conducted on 1 control and 3 trial groups each consisted of 10 overiectomized rats. Control group received sesame oil while progesterone group received 2 mg/rat/day progesterone, estrogen group 10 mg/rat/day 17β-estradiol and estrogen + progesteron group 10 mg/rat/day 17β-estradiol+ 2 mg/rat/ day progesterone for 10 days. Blood samples of rats were collected under general anesthesia after 2 hours following last administration and checked for malondialdehyde (MDA), AOA, β-carotene, vitamin A, and C levels.<p> <b>Results:</b> Whole blood MDA levels in estrogen group were decreased as compared to control group while remained same in others. Plasma AOA levels of estrogen and estrogen + progesterone groups were higher (p<0.05) than control and progesterone groups. Plasma β-carotene levels were decreased in all trial groups when compared to control. Vitamin C levels of all groups were higher as compared to control group and were highest in estrogen + progesterone group.<p> <b>Conclusion:</b> It can be concluded that estrogen decreases lipid peroxidation and increases antioxidant capacity besides effects positively the levels of antioxidant vitamins, particularly showing that mentioned level of estrogen act as an antioxidant.http://eurasianjvetsci.org/pdf.php3?id=854lipid peroxidationestrogenprogesteronevitamin avitamin c |
| spellingShingle | Aziz Bulbul Recep Aslan H. Ahmet Celik Gulcan Avci Fatih Fidan Effects of ovarian steroids on oxidative stress in overiectomized rats Eurasian Journal of Veterinary Sciences lipid peroxidation estrogen progesterone vitamin a vitamin c |
| title | Effects of ovarian steroids on oxidative stress in overiectomized rats |
| title_full | Effects of ovarian steroids on oxidative stress in overiectomized rats |
| title_fullStr | Effects of ovarian steroids on oxidative stress in overiectomized rats |
| title_full_unstemmed | Effects of ovarian steroids on oxidative stress in overiectomized rats |
| title_short | Effects of ovarian steroids on oxidative stress in overiectomized rats |
| title_sort | effects of ovarian steroids on oxidative stress in overiectomized rats |
| topic | lipid peroxidation estrogen progesterone vitamin a vitamin c |
| url | http://eurasianjvetsci.org/pdf.php3?id=854 |
| work_keys_str_mv | AT azizbulbul effectsofovariansteroidsonoxidativestressinoveriectomizedrats AT recepaslan effectsofovariansteroidsonoxidativestressinoveriectomizedrats AT hahmetcelik effectsofovariansteroidsonoxidativestressinoveriectomizedrats AT gulcanavci effectsofovariansteroidsonoxidativestressinoveriectomizedrats AT fatihfidan effectsofovariansteroidsonoxidativestressinoveriectomizedrats |