Nasal Aβ42 mirrors brain amyloid dynamics and cognitive decline across the Alzheimer’s disease continuum

Nasal Aβ42 mirrors brain amyloid dynamics and cognitive decline across the Alzheimer’s disease continuum

Abstract Early, non-invasive assessment of Alzheimer’s disease (AD) progression remains a key challenge. This study evaluated whether nasal amyloid-β42 (Aβ42) levels reflect brain amyloid dynamics and cognitive decline. Nasal discharge from 161 individuals, ranging from cognitively unimpaired to AD...

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Bibliographic Details
Main Authors: Da Hae Jung, Gowoon Son, Sheng Min Wang, Seung-Jun Yoo, Ali Jahanshahi, Hyun Kook Lim, Cheil Moon
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
Amyloid-β 42
Nasal discharge
Brain amyloidosis
Non-invasive monitoring
Online Access:https://doi.org/10.1038/s41598-025-15230-2
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