Levels of parathyroid hormone and IGF binding protein 1 and associations with mortality and hip fractures in older women
Abstract In this study we examined the effect of simultaneously elevated levels of parathyroid hormone (PTH) (≥ 65 ng/mL) and high levels of insulin-like growth factor-binding protein 1 (IGFBP-1) on the 10-year risk of all-cause mortality and hip fractures. Blood tests for levels of PTH and IGFBP-1...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-80527-7 |
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| author | Elin Uzunel Hans Ranch Lundin Ann-Charlotte Grahn Kronhed Per Wändell Helena Salminen |
| author_facet | Elin Uzunel Hans Ranch Lundin Ann-Charlotte Grahn Kronhed Per Wändell Helena Salminen |
| author_sort | Elin Uzunel |
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| description | Abstract In this study we examined the effect of simultaneously elevated levels of parathyroid hormone (PTH) (≥ 65 ng/mL) and high levels of insulin-like growth factor-binding protein 1 (IGFBP-1) on the 10-year risk of all-cause mortality and hip fractures. Blood tests for levels of PTH and IGFBP-1 was collected at baseline in 338 community-dwelling women in Stockholm aged between 69 and 79 years. Data on hip fractures and all-cause mortality over the next 10 years were retrieved from healthcare registers. The participants were divided into four groups depending on their levels of PTH and IGFBP-1: (A) normal PTH and low IGFBP-1; (B) normal PTH and high IGFBP-1; (C) elevated PTH and low IGFBP-1; (D) elevated PTH and high IGFBP-1. Group D was used as reference. Cox proportional hazard regression (HR) model was used to compare age-adjusted association with hip fractures and all-cause mortality of the four groups. The group with elevated levels of PTH and high IGFBP-1 had a two to three times higher risk of all-cause mortality compared to the other groups but we found no association with hip fractures. |
| format | Article |
| id | doaj-art-959c283af31c42058d7d26411e98e53c |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-959c283af31c42058d7d26411e98e53c2024-12-01T12:18:55ZengNature PortfolioScientific Reports2045-23222024-11-011411810.1038/s41598-024-80527-7Levels of parathyroid hormone and IGF binding protein 1 and associations with mortality and hip fractures in older womenElin Uzunel0Hans Ranch Lundin1Ann-Charlotte Grahn Kronhed2Per Wändell3Helena Salminen4Division of Family Medicine and Primary Care, Department of Neurobiology Care sciences and Society, Karolinska InstitutetDivision of Family Medicine and Primary Care, Department of Neurobiology Care sciences and Society, Karolinska InstitutetDivision of Prevention, Rehabilitation and Community Medicine, Department of Health, Medicine and Caring Sciences, Linköping UniversityDivision of Family Medicine and Primary Care, Department of Neurobiology Care sciences and Society, Karolinska InstitutetDivision of Family Medicine and Primary Care, Department of Neurobiology Care sciences and Society, Karolinska InstitutetAbstract In this study we examined the effect of simultaneously elevated levels of parathyroid hormone (PTH) (≥ 65 ng/mL) and high levels of insulin-like growth factor-binding protein 1 (IGFBP-1) on the 10-year risk of all-cause mortality and hip fractures. Blood tests for levels of PTH and IGFBP-1 was collected at baseline in 338 community-dwelling women in Stockholm aged between 69 and 79 years. Data on hip fractures and all-cause mortality over the next 10 years were retrieved from healthcare registers. The participants were divided into four groups depending on their levels of PTH and IGFBP-1: (A) normal PTH and low IGFBP-1; (B) normal PTH and high IGFBP-1; (C) elevated PTH and low IGFBP-1; (D) elevated PTH and high IGFBP-1. Group D was used as reference. Cox proportional hazard regression (HR) model was used to compare age-adjusted association with hip fractures and all-cause mortality of the four groups. The group with elevated levels of PTH and high IGFBP-1 had a two to three times higher risk of all-cause mortality compared to the other groups but we found no association with hip fractures.https://doi.org/10.1038/s41598-024-80527-7OsteoporosisHip fractureAll-cause mortalityParathyroid hormoneIGFBP-1 |
| spellingShingle | Elin Uzunel Hans Ranch Lundin Ann-Charlotte Grahn Kronhed Per Wändell Helena Salminen Levels of parathyroid hormone and IGF binding protein 1 and associations with mortality and hip fractures in older women Scientific Reports Osteoporosis Hip fracture All-cause mortality Parathyroid hormone IGFBP-1 |
| title | Levels of parathyroid hormone and IGF binding protein 1 and associations with mortality and hip fractures in older women |
| title_full | Levels of parathyroid hormone and IGF binding protein 1 and associations with mortality and hip fractures in older women |
| title_fullStr | Levels of parathyroid hormone and IGF binding protein 1 and associations with mortality and hip fractures in older women |
| title_full_unstemmed | Levels of parathyroid hormone and IGF binding protein 1 and associations with mortality and hip fractures in older women |
| title_short | Levels of parathyroid hormone and IGF binding protein 1 and associations with mortality and hip fractures in older women |
| title_sort | levels of parathyroid hormone and igf binding protein 1 and associations with mortality and hip fractures in older women |
| topic | Osteoporosis Hip fracture All-cause mortality Parathyroid hormone IGFBP-1 |
| url | https://doi.org/10.1038/s41598-024-80527-7 |
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