Sleep quality, APOE ε4, and Alzheimer’s disease: associations from two prospective cohort studies and mechanisms by plasma proteomic analysis

Sleep quality, APOE ε4, and Alzheimer’s disease: associations from two prospective cohort studies and mechanisms by plasma proteomic analysis

Abstract Background The relationship between sleep quality and Alzheimer's disease (AD), and its interaction with genetic susceptibility, remains unclear. Our study explores the complex association between sleep quality and AD risk, focusing on the moderating role of the APOE ε4 allele. Methods...

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Main Authors: Liang-Yu Huang, Lan Tan, Chen-Chen Tan, Xin-Yu Zhang, Xu Lin, Juan-Juan Zou, Yu-Jing Lin, Yu-Ying Zhang, Quan Hao, Zi-Qi Zhang, for the Alzheimer’s Disease Neuroimaging Initiative, Wei Xu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Medicine
Subjects:
Sleep quality index
Cognition
Hippocampal volume
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s12916-025-04255-z
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https://doi.org/10.1186/s12916-025-04255-z

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