Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage
Abstract While autonomic dysregulation and repolarization abnormalities are observed in subarachnoid hemorrhage (SAH), their relationship remains unclear. We aimed to measure skin sympathetic nerve activity (SKNA), a novel method to estimate stellate ganglion nerve activity, and investigate its asso...
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Wiley
2025-01-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70202 |
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| author | Yoichiro Nakagawa Takashi Kusayama Sho Tamai Yuta Nagamori Kazutaka Takeuchi Shuhei Iwaisako Taishi Tsutsui Tomoya Kamide Kouichi Misaki Soichiro Usui Kenji Sakata Mitsutoshi Nakada Masayuki Takamura |
| author_facet | Yoichiro Nakagawa Takashi Kusayama Sho Tamai Yuta Nagamori Kazutaka Takeuchi Shuhei Iwaisako Taishi Tsutsui Tomoya Kamide Kouichi Misaki Soichiro Usui Kenji Sakata Mitsutoshi Nakada Masayuki Takamura |
| author_sort | Yoichiro Nakagawa |
| collection | DOAJ |
| description | Abstract While autonomic dysregulation and repolarization abnormalities are observed in subarachnoid hemorrhage (SAH), their relationship remains unclear. We aimed to measure skin sympathetic nerve activity (SKNA), a novel method to estimate stellate ganglion nerve activity, and investigate its association with electrocardiogram (ECG) alterations after SAH. We recorded a total of 179 SKNA data from SAH patients at three distinct phases and compared them with 20 data from controls. Compared with control data, in the acute phase data (days 1–3 of SAH), T peak‐to‐end (Tp‐e) interval was significantly prolonged (81 [interquartile range {IQR}: 71–93] vs. 58 [IQR: 54–64] ms, p < 0.001), non‐burst amplitude of SKNA was significantly increased (2.4 [IQR: 1.3–4.1] vs. 0.7 [IQR: 0.5–1.7] μV, p < 0.001), and the ratio of low frequency to high frequency (HF) was significantly decreased (0.8 [IQR: 0.5–1.1] vs. 1.1 [IQR: 0.7–1.3], p = 0.028). Linear mixed model revealed a relationship between Tp‐e interval and SKNA. Although these abnormalities gradually normalized, delayed cerebral ischemia episodes were associated with increased HF oscillation. Transient sympathetic dysregulation contributes to repolarization impairment after SAH. SKNA may have the potential to monitor adverse outcomes. |
| format | Article |
| id | doaj-art-9585f893caf34331af7948a378827ac9 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Physiological Reports |
| spelling | doaj-art-9585f893caf34331af7948a378827ac92025-01-15T13:36:31ZengWileyPhysiological Reports2051-817X2025-01-01131n/an/a10.14814/phy2.70202Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhageYoichiro Nakagawa0Takashi Kusayama1Sho Tamai2Yuta Nagamori3Kazutaka Takeuchi4Shuhei Iwaisako5Taishi Tsutsui6Tomoya Kamide7Kouichi Misaki8Soichiro Usui9Kenji Sakata10Mitsutoshi Nakada11Masayuki Takamura12Department of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanDepartment of Neurosurgery Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanDepartment of Health Sciences Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanDepartment of Neurosurgery Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanDepartment of Neurosurgery Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanDepartment of Neurosurgery Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanDepartment of Neurosurgery Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa Ishikawa JapanAbstract While autonomic dysregulation and repolarization abnormalities are observed in subarachnoid hemorrhage (SAH), their relationship remains unclear. We aimed to measure skin sympathetic nerve activity (SKNA), a novel method to estimate stellate ganglion nerve activity, and investigate its association with electrocardiogram (ECG) alterations after SAH. We recorded a total of 179 SKNA data from SAH patients at three distinct phases and compared them with 20 data from controls. Compared with control data, in the acute phase data (days 1–3 of SAH), T peak‐to‐end (Tp‐e) interval was significantly prolonged (81 [interquartile range {IQR}: 71–93] vs. 58 [IQR: 54–64] ms, p < 0.001), non‐burst amplitude of SKNA was significantly increased (2.4 [IQR: 1.3–4.1] vs. 0.7 [IQR: 0.5–1.7] μV, p < 0.001), and the ratio of low frequency to high frequency (HF) was significantly decreased (0.8 [IQR: 0.5–1.1] vs. 1.1 [IQR: 0.7–1.3], p = 0.028). Linear mixed model revealed a relationship between Tp‐e interval and SKNA. Although these abnormalities gradually normalized, delayed cerebral ischemia episodes were associated with increased HF oscillation. Transient sympathetic dysregulation contributes to repolarization impairment after SAH. SKNA may have the potential to monitor adverse outcomes.https://doi.org/10.14814/phy2.70202brain–heart interactionelectrocardiogramrepolarization abnormalityskin sympathetic nerve activitysubarachnoid hemorrhage |
| spellingShingle | Yoichiro Nakagawa Takashi Kusayama Sho Tamai Yuta Nagamori Kazutaka Takeuchi Shuhei Iwaisako Taishi Tsutsui Tomoya Kamide Kouichi Misaki Soichiro Usui Kenji Sakata Mitsutoshi Nakada Masayuki Takamura Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage Physiological Reports brain–heart interaction electrocardiogram repolarization abnormality skin sympathetic nerve activity subarachnoid hemorrhage |
| title | Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage |
| title_full | Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage |
| title_fullStr | Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage |
| title_full_unstemmed | Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage |
| title_short | Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage |
| title_sort | association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage |
| topic | brain–heart interaction electrocardiogram repolarization abnormality skin sympathetic nerve activity subarachnoid hemorrhage |
| url | https://doi.org/10.14814/phy2.70202 |
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