Evolutionary variation of the monkeypox virus detected for the first time in Nantong, Jiangsu
Abstract Monkeypox (MPOX) is a zoonotic disease caused by Orthopoxvirus monkeypox (MPXV), belonging to the Orthopoxvirus genus, and exhibits symptoms similar to smallpox. In 2024, the monkeypox outbreak in the Democratic Republic of the Congo continued to develop, raising widespread global public he...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Virology Journal |
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| Online Access: | https://doi.org/10.1186/s12985-024-02616-3 |
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| author | Xingpei Ji Ruyue Liang Chao Bao Xiuli Cai Shiyao Chen Lu Chen Li Li Xiaolei Ji |
| author_facet | Xingpei Ji Ruyue Liang Chao Bao Xiuli Cai Shiyao Chen Lu Chen Li Li Xiaolei Ji |
| author_sort | Xingpei Ji |
| collection | DOAJ |
| description | Abstract Monkeypox (MPOX) is a zoonotic disease caused by Orthopoxvirus monkeypox (MPXV), belonging to the Orthopoxvirus genus, and exhibits symptoms similar to smallpox. In 2024, the monkeypox outbreak in the Democratic Republic of the Congo continued to develop, raising widespread global public health concerns. In September 2023, the first local monkeypox outbreak was reported in Nantong, Jiangsu Province, China. Whole-genome sequencing of samples from seven confirmed patients identified a new lineage, C.1.1, which may be related to imported cases from Japan. Evolutionary analysis of MPXV showed fewer mutations mediated by Apolipoprotein B mRNA Editing Catalytic polypeptide-like 3 (APOBEC3). Additionally, mutations in the N2L protein disrupted transcription initiation, while changes in the Cytomegalovirus-encoded immunomodulatory protein B (CrmB) led to structural instability of the protein. It is hoped that these findings will provide insights for future research on the evolutionary mechanisms of the monkeypox virus and the development of vaccines. |
| format | Article |
| id | doaj-art-95505af587414e4eaf6f08b0621aa3fe |
| institution | Kabale University |
| issn | 1743-422X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj-art-95505af587414e4eaf6f08b0621aa3fe2024-12-29T12:10:23ZengBMCVirology Journal1743-422X2024-12-0121111110.1186/s12985-024-02616-3Evolutionary variation of the monkeypox virus detected for the first time in Nantong, JiangsuXingpei Ji0Ruyue Liang1Chao Bao2Xiuli Cai3Shiyao Chen4Lu Chen5Li Li6Xiaolei Ji7Key Laboratory of Medicine, Nantong Center for Disease Control and PreventionKey Laboratory of Medicine, Nantong Center for Disease Control and PreventionKey Laboratory of Medicine, Nantong Center for Disease Control and PreventionKey Laboratory of Medicine, Nantong Center for Disease Control and PreventionKey Laboratory of Medicine, Nantong Center for Disease Control and PreventionKey Laboratory of Medicine, Nantong Center for Disease Control and PreventionKey Laboratory of Medicine, Nantong Center for Disease Control and PreventionKey Laboratory of Medicine, Nantong Center for Disease Control and PreventionAbstract Monkeypox (MPOX) is a zoonotic disease caused by Orthopoxvirus monkeypox (MPXV), belonging to the Orthopoxvirus genus, and exhibits symptoms similar to smallpox. In 2024, the monkeypox outbreak in the Democratic Republic of the Congo continued to develop, raising widespread global public health concerns. In September 2023, the first local monkeypox outbreak was reported in Nantong, Jiangsu Province, China. Whole-genome sequencing of samples from seven confirmed patients identified a new lineage, C.1.1, which may be related to imported cases from Japan. Evolutionary analysis of MPXV showed fewer mutations mediated by Apolipoprotein B mRNA Editing Catalytic polypeptide-like 3 (APOBEC3). Additionally, mutations in the N2L protein disrupted transcription initiation, while changes in the Cytomegalovirus-encoded immunomodulatory protein B (CrmB) led to structural instability of the protein. It is hoped that these findings will provide insights for future research on the evolutionary mechanisms of the monkeypox virus and the development of vaccines.https://doi.org/10.1186/s12985-024-02616-3Monkeypox virusPhylogenetic analysisSingle nucleotide polymorphismAPOBEC3 |
| spellingShingle | Xingpei Ji Ruyue Liang Chao Bao Xiuli Cai Shiyao Chen Lu Chen Li Li Xiaolei Ji Evolutionary variation of the monkeypox virus detected for the first time in Nantong, Jiangsu Virology Journal Monkeypox virus Phylogenetic analysis Single nucleotide polymorphism APOBEC3 |
| title | Evolutionary variation of the monkeypox virus detected for the first time in Nantong, Jiangsu |
| title_full | Evolutionary variation of the monkeypox virus detected for the first time in Nantong, Jiangsu |
| title_fullStr | Evolutionary variation of the monkeypox virus detected for the first time in Nantong, Jiangsu |
| title_full_unstemmed | Evolutionary variation of the monkeypox virus detected for the first time in Nantong, Jiangsu |
| title_short | Evolutionary variation of the monkeypox virus detected for the first time in Nantong, Jiangsu |
| title_sort | evolutionary variation of the monkeypox virus detected for the first time in nantong jiangsu |
| topic | Monkeypox virus Phylogenetic analysis Single nucleotide polymorphism APOBEC3 |
| url | https://doi.org/10.1186/s12985-024-02616-3 |
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